Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/13658
標題: 鉻與乳鐵蛋白對C57BL/6JNarl小鼠醣類及脂質代謝之影響
Effects of chromium and lactoferrin on carbohydrate and lipid metabolism in C57BL/6JNarl mice
作者: 陳郁淳
Chen, Yu-Chun
關鍵字: Chromium;鉻;Lactoferrin;乳鐵蛋白
出版社: 獸醫學系暨研究所
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摘要: 
研究指出微量元素鉻可促進醣類及脂質代謝並增加胰島素敏感性,然而少數文獻指出單獨使用乳鐵蛋白即有相似之功效。本研究利用雄性C57BL/6JNarl (B6) 小鼠來探討鉻元素 (Cr)、乳鐵蛋白 (Lf) 以及兩者合併使用對B6小鼠能量代謝之影響。分別給予B6小鼠四種不同脂質及鉻含量之飼料,發現給予高鉻飲食使血糖值降低並改善其葡萄糖耐受性。將高脂飲食之B6小鼠分為4組,分別為給予Cr、Lf、Cr Lf合併給予以及控制組 (CTRL),餵飼四週後發現合併給予Cr Lf使體重增加量以及肝臟重量明顯減少,但單獨給予Cr或Lf則無法減少體重之增加,由糞便以及尿液中的Cr含量推測,合併給予Cr Lf的組別對Cr之吸收率較單獨給予Cr或Lf的組別高。因此推論,合併使用Cr Lf 可增加Cr的吸收率,並藉由促進脂肪的代謝,減少脂肪組織堆積,導致體重的增加量減少。

Previous studies showed that chromium can improve carbohydrate and lipid metabolism, and also increase insulin sensitivity. Recently, a study indicated that a similar result was found when supplemented with lactoferrin alone. In this study, male C57BL/6JNarl (B6) mice were used to reexamine the effects of chromium (Cr), lactoferrin (Lf) and the combination of Cr and Lf on energy metabolism. B6 mice were fed with four different diets containing different levels of fat and Cr. Mice fed with high Cr diets showed lower levels of fasting blood glucose concentrations and improvement in glucose tolerance test. In the second experiment, supplementation with Cr, Lf, or both were tested in high fat fed mice. After a four weeks supplement, mice with Cr Lf showed lower liver weight and lower body weight gain compared with Cr or Lf alone. A trend of higher Cr content was also found in Cr Lf group. We speculate that using Cr and Lf together can increase the absorption of Cr which promotes lipid metabolism and reduces fat accumulation that leads to less body weight gain.
URI: http://hdl.handle.net/11455/13658
其他識別: U0005-2907200814075400
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