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Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/13664
標題: 外源性生長激素刺激素對發身前與發身後貓隻生長激素調控之作用
The effect of exogenous growth hormone releasing hormone on the regulation of growth hormone in prepubertal and pubertal cats
作者: 辛美月
Singhanetr, Sasisopa
關鍵字: prepubertal;發身前;pubertal;cats;GHRH;發身後;貓;生長激素刺激素
出版社: 獸醫學系暨研究所
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Measurements of growth hormone and insulin-like growth factor 1 in cats with diabetes mellitus. Vet Rec 158:195-200, 2006. Rigamonti AE, Marazzi N, Cella SG, Cattaneo L, Muller EE. Growth hormone responses to growth hormone-releasing hormone and hexarelin in fed and fasted dogs: effect of somatostatin infusion or pretreatment with pirenzepine. J Endocrinol 156: 341-348, 1998. Rijnberk A. Protocols for function tests. In: Rijnberk A, ed. Clinical endocrinology of dogs and cats- an illustrated text. Kluwer academic publisher: Dordrecht. 205-212, 1996. Rijnberk A, Kooistra HS, Mol JA. Endocrine diseases in dogs and cats: similarities and differences with endocrine diseases in humans. Growth Horm IGF Res 13: 158-164, 2003. Rizvia SSR, Altaf S, Latif S, Naseemc AA, Afzala M, Qayyum M. Chronic orchidectomy does not influence the sensitivity of the pituitary somatotropes to varying doses of GHRH administered intravenously to the adult male rhesus monkey. Life Sci 75: 1041-1050, 2004. Skinner DC, Head S, Oliver J. Growth hormone-releasing hormone neurons in the anestrus cat do not express progesterone receptors. Cell Tissue Res 311:267-270, 2003. Starkeya SR, Tanc K, Churchb DB. Investigation of serum IGF-I levels amongst diabetic and non-diabetic cats. J Feline Med Surg 6: 149-155, 2004. ThidarMyint H, Yoshida H, Ito T, Heb M, Inoue H, Kuwayamaa H. Combined administration of ghrelin and GHRH synergistically stimulates GH release in Holstein preweaning calves. Domest Anim Endocrinol 34:118-123, 2008. Turner AI, Hemsworth PH, Tilbrook AJ. Susceptibility of reproduction in female pigs to impairment by stress or elevation of cortisol. Domest Anim Endocrinol 29: 398-410, 2005. Veldhuis JD, Anderson SM, Shah N, Bray M, Vick T, Gentili A, Mulligan T, Johnson ML, Weltman A, Evans WS Iranmanesh A. Neurophysiological regulation and target-tissue impact of the pulsatile mode of growth hormone secretion in the human. Growth Horm IGF Res 11: 25-37, 2001. Veldhuis JD, Evans WS, Iranmanesh A, Weltman AL, Bowers CY. Short-Term Testosterone Supplementation Relieves Growth Hormone Autonegative Feedback in Men. J Clin Endocrinol Metab 89: 1285-1290, 2004. Veldhuis JD, Metzger DL, Martha PM, Mauras N, Kerrigan JR, Keenan B, Rogol AD, Pincus SM. Estrogen and testosterone, but not a nonaromatizable androgen, direct network integration of the hypothalamo-somatotrope (Growth Hormone)-insulin- like growth factor I axis in the human: evidence from pubertal pathophysiology and sex-steroid hormone replacement. J Clin Endocrinol Metab 82: 3414 -3420, 1997. Veldhuis JD, Roemmich JN, Richmond EJ, Bowers CY. Somatotropic and Gonadotropic Axes Linkages in Infancy, Childhood, and the Puberty-Adult Transition. Endocr Rev 27: 101-140, 2006. Veldhuis JD, Roemmich JN, Richmond EJ, Rogol AD, Lovejoy JC, Moore MS, Mauras N, Bowers CY. Endocrine Control of Body Composition in Infancy, Childhood, and Puberty. Endocr Rev 26: 114-146, 2005. 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摘要: 
生長激素刺激素是一種從下視丘分泌出來的縮氨酸，它能刺激腦下垂體前葉的生長激素分泌細胞分泌生長激素。生長激素是一種調控身體生長、身體發育與身體組成的主要荷爾蒙。生長激素是呈現脈搏式的分泌方式，并於大多數的動物呈現性別上的差異。生長激素的分泌同時受到年齡、性別、身體組成等因素的影響。在此次的實驗的目的，我們主要是針對外源性生長激素刺激素對於發身前與發身後貓隻腦下垂體釋放生長激素的觀察，以及不同劑量生長激素刺激素對發身後腦下垂體分泌生長激素的影響。結果顯示使用1 µg/kg 生長激素刺激素並不會於發身前與發身後貓隻提升生長激素分泌，同時2 and 4 µg/kg 生長激素刺激素也不會提升發身後貓隻生長激素分泌。公貓與母貓的基礎生長激素濃度並無顯著性差異。雖然胰島素樣生長因子-I並不會因為生長激素刺激素的使用而增加，但是發身後母貓隻的胰島素樣生長因子-I低於公貓，并達到顯著性差異，同樣的，發身前公貓的胰島素樣生長因子-I濃度顯著高於同時期的母貓。在此實驗中並無觀察到血糖與血漿中可體松濃度，會因為生長激素刺激素的刺激而有所不同。因此於此實驗顯示無論於發身前或是發身後貓隻的生長激素、胰島素樣生長因子-I、血糖以及血漿中可體松的濃度，並不會因為生長激素刺激素的刺激而有所改變。同時，胰島素樣生長因子-I 濃度的不同具有性別上的差異，而且是從發身前就已經發現到了。胰島素樣生長因子-I 的濃度會隨著年齡的增加而遞減。

Growth hormone releasing hormone (GHRH) is a hypothalamic peptides that stimulates GH secretion. Growth hormone (GH) is a major regulator of growth, somatic development and body composition; it is secreted in a pulsatile manner which is sexually dimorphic in most mammalian species, and affected by age, gender, body composition and so on. In this study, we aim to investigate the GH response to exogenous GHRH for determining pituitary functions in the cats (4 females, 4 males) in different age (5, 11, 17, and 21 months). Different doses of GHRH (1, 2, and 4 µg/kg) were infused intravenously in pubertal cats. The administration of 1 µg/kg GHRH did not result in the change of plasma GH level in both prepubertal and pubertal cats, as well as 2 and 4 µg/kg GHRH in pubertal cats, and there were no significant different in basal plasma GH level between male and female cats. Although the change of plasma IGF-1 level after GHRH administration was not observed, however, we found that pubertal female cats had significantly lower basal plasma IGF-1 level than prepubertal period (p<0.01), and male cats had significantly higher basal plasma IGF-1 level than female since prepubertal period (p<0.01). There were no glucose and cortisol response to GHRH observed as well. In conclusion, exogenous GHRH did not stimulate GH, IGF-1, glucose, and cortisol secretion in both prepubertal and pubertal cats. The present study suggest that plasma IGF-1 level of the cats were reducing by age, and the different of plasma IGF-1 level could be observed since prepubertal period.
URI: http://hdl.handle.net/11455/13664
其他識別: U0005-2907200817071600
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