Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/14384
標題: 冬蟲夏草對鏈佐菌素誘發糖尿病大鼠血糖之影響
Effects of Cordyceps sinensis on Blood Glucose in STZ-induced Diabetic Rats
作者: 陳泰佑
Chen, Tai-You
關鍵字: 冬蟲夏草;Cordyceos sinensis;鏈佐菌素;糖尿病大鼠;血糖;Blood Glucose;STZ-induced Diabetic Rats
出版社: 獸醫學系暨研究所
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摘要: 
近年來研究認為糖尿病與新陳代謝症候群息息相關,目前糖尿病藥物有磺醯尿素類(Sulfonylurea)、雙胍類(Biguanides)、甲型葡萄糖抑制劑(alpha-glucosidase inhibitor)、thiazolidinediones(TZDs)、胰島素(insulin)及二肽基胜肽酶-4 抑制劑(dipeptidyl peptidase-4 inhibitor)等,各有其適應症且亦有許多不良藥物反應。因而許多研究人員欲研發藥品或萃取天然成分來改善新陳代謝症候群而控制糖尿病,甚至達到預防效果。文獻指出,冬蟲夏草含有多種活性成分,有增加葡萄糖轉運蛋白數量,有穩定血糖作用。因此,本研究以直接管餵冬蟲夏草液方式給予經由鏈佐菌素(Streptozotocin)所誘發糖尿病大白鼠,以尾端採血方式採取血液,用血糖機(one touch TM)及測量試紙每兩日測量其血糖值。實驗數據發現,每日一次管餵冬蟲夏草成分,可提升糖尿病大鼠血糖控制能力。由上述實驗結果顯示,冬蟲夏草控制血糖作用可能藉影響身體組織對葡萄糖利用率,而達穩定血糖效果。

In recent years, researches indicate diabetes implicated in metabolic syndrome. There are sulfonylurea, bioguanides, alpha-glucosidase inhibitor, thiazolidinediones, insulin, dipeptidyl peptidase-4 inhibitors and so on in diabetic drugs which have their indication and a lot of side effects. Therefore, many researchers develop drugs or extraction for natural products to improve metabolic syndrome and control diabetes, and moreover can reach prevention. Cordyceps has a large amount of biological ingredients which increase numbers of transporter proteins and stablelize concentration of blood glucose. Therefore, we found Cordyceps extract could prevent hyperglycemia in STZ-induced diabetic rats.
URI: http://hdl.handle.net/11455/14384
其他識別: U0005-2907201316495800
Appears in Collections:獸醫學系所

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