Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/1538
標題: 非侵入式近紅外線光學血糖感測器之研究
Study on Non-Invasive Near Infrared Optical Blood Glucose Sensor
作者: 林胤宏
Lin, Yin-Hong
關鍵字: Non-Invasive;非侵入式;Glucose;Infrared Sensor;Optical;血糖;紅外線感測器;光學
出版社: 機械工程學系所
引用: [1] 耕莘醫院 http://www.cth.org.tw/00news/news04_970412-1.html [2] 高雄榮民總醫院新陳代謝科醫檢師王玫君http://www.vghks.gov.tw/meta/periodical/SMBG.pdf [3] 羅氏血糖儀公司 http://www.accu-chek.com.tw/pdt01.html [4] 美敦力血糖儀生技公司http://www.medtronic.com.hk/index.htm [5] M. R. Robinson, R. P. Eaton, D. M. Haaland, G. W. Koepp, E. V. Thomas, B. R. Stallard, P. L. Robinson, “Noninvasive glucose monitoring in diabetic patients: A preliminary evaluation,” Clin. Chem., Vol. 38, pp. 1618-1622, 1992. [6] C. Chou, C. Y. Han, W. C. Kuo, Y. C. Huang, C. M. Feng, J. C. Shyu,“Noninvasive glucose monitoring in vivo with an optical heterodyne polarimeter,”Applied Optics, Vol. 37, p. 3553, 1998. [7] W. H. Wang, C. Y. Han, P. C. Tu, C. Chou,“In vivo, noninvasive glucose monitoring with optical heterodyne polarimetry in a range of 50 mg/dl to approximately 100 mg/dl,” Proceedings of SPIE The International Society for Optical Engineering, Vol. 4082, pp. 192-197, 2000. [8] K. Maruo, M. Tsurugi, J. Chin, T. Ota, H. Arimoto, Y. Yamada, M. M. Tamura, M. Ishii, Y. Ozaki, “Noninvasive Blood Glucose Assay Using A Newly Developed Near Infrared System,” IEEE Journal of Selected Topics in Quantum Electronics, Vol. 9, No. 2, pp. 322-330, 2003. [9] A. Caduff, E. Hirt, Y. Feldman, Z. Ali, L. Heinemann,“First human experiments with a novel non-invasive, non-optical continuous glucose monitoring system,” Biosensors and Bioelectronics, Vol. 19, pp. 209-217, 2003. [10] K. X. Xu, Q. Y. Qiu, J. Y. Jiang, X. Y. Yang, “Non-invasive glucose sensing with near-infrared spectroscopy enhanced by optical measurement conditions reproduction technique,” Optics and Lasers in Engineering, Optical Metrology in China, Vol. 43, pp. 1096-1106, 2005. [11] R. Liu, W. L. Chen, X. Y. Gu, R. K. Wang, K. X. Xu,“Chance correlation in non-invasive glucose measurement using near-infrared spectroscopy,” Journal of Physics , Vol. 38, pp. 2675-2681, 2005. [12] T Morikawa; F Saiki; H Ishizawa; E Toba, “Noninvasive measurement of blood glucose based on optical sensing and internal standard method,” SICE Icase International Joint Conference, pp. 1481-1484, 2006. [13] F. Saiki, H. Ishizawa, A. Muro, E. Toba,“Noninvasive measurement of blood glucose based on optical sensing and internal standard method,” Proceedings of the SICE Annual Conference, SICE Annual Conference, pp. 783-786, 2007. [14] M. Ogawa, Y. Yamakoshi, M. Satoh, M. Nogawa, T. Yamakoshi, S. Tanaka, P. Rolfe, T. Tamura, K. I. Yamakoshi,“Support vector machines as multivariate calibration model for prediction of blood glucose concentration using a new non-invasive optical method named pulse glucometry,” Annual International Conference of the IEEE Engineering in Medicine and Biology-Proceedings, pp. 4561-4563, 2007. [15] X. Zhang, C. M. Ting, J. H. Yeo,“Finger temperature controller for non-invasive blood glucose measurement,” Progress in Biomedical Optics and Imaging - Proceedings of SPIE,Optics in Health Care and Biomedical Optics IV, Vol. 7845, pp. 78452X-78452X-6, 2010. [16] H. F. Yao, A. J. Shum, M. Cowan, I. Lähdesmäki, B. A. Parviz,“A contact lens with embedded sensor for monitoring tear glucose level,” Biosensors and Bioelectronics, Vol. 26, pp. 3290-3296, 2011. [17] M. Chu, K. Miyajima, D. Takahashi, T. Arakawa, K. Sano, S. Sawada, H. Kudo, Y. Iwasaki, K. Akiyoshi, M. Mochizuki, K. Mitsubayashi,“Soft contact lens biosensor for in situ monitoring of tear glucose as non-invasive blood sugar assessment,” Talanta, Vol. 83, pp. 960-965, 2011. [18] Z. H. Huang, C. N. Hao, L. L. Zhang, Y. C. Huang, Y. Q. Shi, G. R. Jiang, J. L. Duan, “Noninvasive blood glucose sensing on human body with near-infrared reflection spectroscopy,” Proceedings of SPIE The International Society for Optical Engineering, Vol. 8193, pp. 81931O-81931O-10, 2011. [19] 財團法人國家實驗研究院國家奈米元件實驗室南區分中心 [20] 毛光興,儀器分析,幼獅文化事業公司,1971。 [21] 朱世盛,儀器分析,復旦大學出版社,1991。 [22] 邱念華,儀器分析實驗,新文京開發出版股份有限公司,2003。 [23] 鄭新讚,儀器分析II,全華科技圖書股份有限公司,2006。 [24] 吳振成、田憲儒、陳義雄、卓靜哲、葉茂榮、郭建志,普通化學上冊,狀元出版社,1979。 [25] 游瑞成,有機光譜學,徐氏基金會出版,1987。 [26] 陳陵援、吳慧眼,儀器分析,三民書局股份有限公司,1996。 [27] Epitex科技公司 www.epitex.com/products/led_plastic_mold/pdfs/L970-03.pdf [28] OSI光電科技公司 www.osioptoelectronics.no/OSI-Optoelectronics-Catalog.pdf [29] 賴耿陽,紅外線工學基礎應用,台灣復文興業股份有限公司,1995。 [30] 莊達人,VLSI製造技術,高立圖書有限公司,2003。 [31] 曹恆偉,林浩雄,郭建宏,陳建中,微電子電路(上),台北圖書有限公司,2004。 [32] UA741 http://www.datasheetcatalog.org/datasheet/texasinstruments/ua741.pdf [33] Harold B. Killen,光纖通訊,高立圖書有限公司,1998。 [34] 盧明智、盧鵬任,感測器應用與線路分析,全華科技圖書股份有限公司,2002。 [35] 安毓英、曾小東,光學感測與量測,五南圖書出版股份有限公司,2004。 [36] 原榮,光纖通訊系統:原理與應用,新文京開發出版股份有限公司,2004。 [37] Chun Nan Chen,Joseph C. Palais,光纖通訊與應用,新文京開發出版股份有限公司,2004。 [38] 陳國群,最新糖尿病精要,藝軒圖書出版社,1996。 [39] Stanton A. Glantz,簡明生物統計學,合計書局有限公司,1999。 [40] 華廣生技公司 http://www.bionime.com/diabetes/ [41] W. L. Clarke, D. Cox, L. A. G. Frederick, W. Carter, S. L. Pohl,“Evaluating clinical accuracy of systems for self-monitoring of blood glucose,” Diabetes Care, Vol. 10, pp. 622-628, 1987. [42] R. Badugu, J. R. Lakowicz, C. D. Geddes,“A Glucose sensing contact lens: A new approach to non-invasive continuous physiological glucose monitoring,” Proceedings of SPIE The International Society for Optical Engineering, Vol. 5317, pp. 234-245, 2004. [43] X. Gu, B. Deng, L. An, W. L. Chen, K. Xu,“The feasibility investigation of non-invasive blood glucose sensing based on near-infrared spectroscopy,” Progress in Biomedical Optics and Imaging - Proceedings of SPIE, Vol. 6094, pp. 109-116, 2006. [44] R. Liu, X. Y. Gu, K. X. Xu,“Research on the background correction in the non-invasive sensing of glucose by near-infrared spectroscopy,” Guang Pu Xue Yu Guang Pu Fen Xi/Spectroscopy and Spectral Analysis, Vol. 28, pp. 1772-1775, 2008. [45] H. Ishizawa, A. Muro, T. Takano, K. Honda, H. Kanai,“Non-invasive Blood Glucose Measurement Based on ATR Infrared Spectroscopy,” International Conference on Instrumentation,Control and Information Technology, pp. 321-324, 2008.
摘要: 
本論文發展一非侵入式紅外線光學血糖感測系統,針對無痛、快速、小體積為目標,以及探討血糖感測系統之可行性。感測原理是使用紅外線發光二極體之光源照射人體手指頭皮膚,由紅外線光射入皮膚層後,使人體血液中的血糖吸收此特定紅外線波長,當吸收過紅外線波長的血糖在血液中流動時,其紅外線光感測器所感測訊號是入射光打到血糖後所反射的輻射能;使光感測器接收的光功率能量增加,而光感測器所轉換之電流亦增加。當電流經由光感測器的放大電路放大訊號,並轉換為電壓輸出訊號。為了提高感測系統之穩定性,將利用夾具使手指固定,以避免感測器受到環境光源干擾。本系統之光線提供為970 nm之紅外線光源,光感測器之響應度在970 nm處有0.58 A/W。由模擬計算血糖在90 ~ 180 mg/dL之間,相對輸出電壓在1.42 ~ 1.52 V。完成組裝紅外線光學血糖感測器之工作,經實驗結果顯示,量測血糖90 ~ 180 mg/dL之範圍,輸出電壓在1.43 ~ 1.54 V,此實驗結果接近模擬結果。

This study develops a non-invasive infrared optical blood glucose sensor. The advantages of the sensor are against painless, fast response and low cost. The infrared optical blood glucose sensor consists of infrared light diodes, a finger hold, a photodetector and an amplifier circuit. The working principle of the sensor describes as follows. A human puts a finger into the finger hold, and the infrared diodes provide an infrared light into the finger skin. The glucose in the human blood absorbs a specific infrared wavelength, and irradiated an infrared power to the photodetector. Then, the photodetector transfers the infrared power into a current. The amplifier circuit is utilized to converts the output current of photodetector into an output voltage. In order to increase the testing stability, the finger hold was fabricated to avoid ambient light interference, and it was made from the polymer. The infrared diodes supplied an infrared light of 970 nm, and the responsivity of the photodetector was about 0.58 A/W at 970 nm. The simulated results showed that the output voltage of the sensor changed from 1.42 to 1.52 V as the blood glucose increased from 90 to 180 mg/dL. The work has completely assembled the infrared optical blood glucose sensor. The experimental results depicted that the output voltage of the sensor varied from 1.43 to 1.54 as the blood glucose increased from 90 to 180 mg/dL, and the results was approached the simulated results.
URI: http://hdl.handle.net/11455/1538
其他識別: U0005-1101201210114800
Appears in Collections:機械工程學系所

Show full item record
 

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.