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標題: 利用簡單的氯化銅系統進行碳-碳三鍵偶合反應、環合反應及碳-硫偶合反應以完成一鍋合成苯駢[b]&;#22139;吩衍生物之研究
The study in cascade reactions of Csp2-Csp cross-coupling(Sonogashira-type reaction)、cyclization and Csp2-S cross-coupling(Ullmann-type reaction) for one-pot three-step synthesis of benzo[b]thiophene derivatives using a simple copper-chloride system.
作者: 林哲毅
Lin, Zhe-Yi
關鍵字: benzo[b]thiophene
出版社: 化學系所

It has been known that 2,3-disubstituted benzo[b]thiophenes have been prepared in excellent yields via coupling of terminal alkynes with commercially available o-iodothioanisole in the presence of a palladium catalyst and subsequent electrophilic cyclization of the resulting o-(1-alkynyl)thioanisole derivatives.
We have developed a new synthetic method that by using copper choride-mediated cascade reactions of Csp2-Csp coupling, intramolecular cyclization, and Csp2-S coupling without using palladium catalyst and any ligand for one-pot three-step syntheses of 2,3-disubstituted benzo[b]thiophenes.
Appears in Collections:化學系所

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