Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/16753
標題: 聚乙烯醇與聚丙烯酸複合水膠薄膜在藥物釋放上之研究
Drug Release Behavior of Hydrogel Membrane composites based on Poly(vinyl alcohol)/Poly(acrylic acid)
作者: 詹騏銘
Chan, Chi-Ming
關鍵字: poly(vinyl alcohol);聚乙烯醇;poly(acrylic acid);hydrogel;drug release;聚丙烯酸;水膠;藥物釋放
出版社: 化學系所
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摘要: 
本論文中使用戊二醛(Glutaraldehyde)對聚乙烯醇(polyvinyl alcohol, PVA)/聚丙烯酸(polyacrylic acid, PAA)進行交聯反應製備化學水膠。藉由聚丙烯酸直鏈性高分子之摻入形成半互穿型聚合網絡(semi-Interpenetrating Polymer Networks, semi-IPNs),使得聚乙烯醇水膠具有酸鹼敏感之特性,可應用於胃道與腸道酸鹼環境不同之選擇性釋放,並以FT-IR、DSC、XRD等儀器鑑定所製備水膠之組成與物性。
在此論文中選用Acetaminophen此低分子量、水溶性良好之藥物作為model drug了解水膠薄膜對藥物在水中溶離速率的影響。發現在不同交聯度下,水膠在膨潤動力學以及藥物釋放行為產生改變,發現交聯度與膨潤程度、速率成反比關係,而藥物釋放的速率則與膨潤動力學表現相符合。此外,聚丙烯酸的摻混程度,則顯著地影響水膠在不同pH值環境下之膨潤程度,當聚丙烯酸含量越高,在酸性環境膨潤的表現越不明顯,也因此藥物釋放速率緩慢;當環境之pH升高至中性時,由於羧基轉為解離態之羧酸根,產生電荷排斥力使得高分子鏈舒張,交聯網目亦被撐大故膨潤速率增加,藥物釋放速率變快。在前180分鐘為零階動力釋放行為,在中性環境之釋放速率為酸性環境的2倍。

Smart hydrogel, the semi-interpenetration polymer network system (semi-IPNs) composed of pH-sensitive polyacrylic acid (PAA) trapped with polyvinyl alcohol (PVA) in the present of glutaraldehyde (GA) as the cross-linker, is prepared for application in drug delivery of Acetaminophen. The structure and properties of as-produced hydrogels were investigated by Fourier transform infrared (FT-IR) analysis, Differential Scanning Calorimetry (DSC), X-ray diffraction pattern (XRD). Swelling rate of PVA hydrogels is inversely proportional to the cross-linker density, indicating the drug release rate from such hydrogels is determined by a density of the net and is lowered by a increase in the PVA : GA mass ratio. The swelling behaviors of PVA/PAA hydrogels and drug release from the hydrogels in relation to pH were investigated. As in neutral environment, the swelling velocity was much improved by introducing PAA in comparison with non-PAA, which is due to the enhancement of the entanglement of this hydrogel network resulted from electrostatic repulsive interaction of carboxylic (COO-) group. It indicated that the PAA introduced hydrogel system provided a suitable release profile for drug delivery vehicle.
URI: http://hdl.handle.net/11455/16753
其他識別: U0005-2307200914264600
Appears in Collections:化學系所

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