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Doxorubicin-mediated transient tNOX up-regulation leading to enhanced cell migration in A549 lung cancer cells
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tNOX (tumor-associated NADH oxidase)是屬於一種與細胞生長有關的膜外-NADH氧化
tNOX (tumor-associated NADH oxidase) belongs to an ECTO-NOX family of growth-related NADH oxidases. Since over-expressing tNOX leads to cells transforming, enhanced invasion ability and exhibited more responsive to anticancer drugs. On the other hand, HeLa cell growth and migration are reduced by tNOX-knockdown utilizing RNA interference technique, implying that tNOX is associated with transformed cells proliferation, migration and invasive ability. Doxorubicin (adriamycin), a long-time use in clinical cancer treatment, has been demonstrated to be a target of tNOX. Here, we confirmed that the expression of tNOX is inhibited by doxorubicin treatments at both protein and RNA levels. Interestingly, the expression of tNOX is transiently enhanced by short-time exposure of lower concentrations of doxorubicin in association with increased A549 cells migration and proliferation, suggesting that the level of tNOX expression is important for aggressive cancer cell phenotypes. To explore tNOX function more deeply, we found a serine504 mutation on tNOX exhibits enhanced tNOX function in cell proliferation, migration and different responses against doxorubicin treatment compared to wild type tNOX.
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