Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/2175
標題: T型微流道乳化液滴生成與控制之研究
Generation and Manipulation of Droplet Emulsions at the T-junction in Microfluidic Channels
作者: 林祐駿
Lin, You-Chun
關鍵字: T-junction;T型微流道;droplet emulison;乳化液滴
出版社: 機械工程學系所
引用: 參考文獻 Burns, M. A., Johnson, B. N., Brahmasandra, S. N., Handique, K., Webster, J. R., Krishnan, M., Sammarco, T. S., Man, P. M., Jones, D., Heldsinger, D., Mastrangelo, C. H. and Burke, D. T., “An integrated nanoliter DNA analysis device,” Science, Vol. 282, 1998, pp.484-487. Erickson, D. and Li, D., “Integrated microfluidic devices,” Analytica Chimica Acta, Vol. 507, 2004, pp. 11-26. Garstecki, P., Fuerstman, M. J., Stonec, H. A., Whitesides, G. M., “Formation of droplets and bubbles in a microfluidic T-junction—scaling and mechanism of break-up,” Lab on a Chip, Vol. 6, 2006, pp. 437-446. Hung, L. H., Choi, K. M., Tseng, W. Y., Tan, Y. C., Shea, K. J. and Lee, A. P., “Alternating droplet generation and controlled dynamic droplet fusion in microfluidic device for CdS nanoparticle synthesis,” Lab on a Chip, Vol. 6, 2006, pp. 174-178. Handique, K. and Burns, M. A., “Mathematical modeling of drop mixing in a slit-type Microchannel,” J. Micromech. Microeng, Vol. 11, 2001, pp. 548-554. Hsiung, S. K., Chen, C. T. and Lee, G. B., “Micro-droplet formation utilizing microfluidic flow focusing and controllable moving-wall chopping techniques,” J. Micromech. Microeng, Vol. 16, 2006, pp. 2403-2410. Huang, K. S., Lai, T. H. and Lin, Y. C., “Manipulating the generation of Ca-alginate microspheres using microfluidic channels as a carrier of gold nanoparticles,” Lab on a Chip, Vol. 6, 2006, pp. 954-957. Haeberle, S., Zengerle, R., Ducree, J., “Centrifugal generation and manipulation of droplet emulsions,” Microfluid Nanofluid, Vol. 3, 2007, pp. 65-75. Link, D. R., Anna, S. L., Weitz, D. A. and Stone, H. A., “Geometrically mediated break up of drops in microfluidic devices,” Physical Review Letters, Vol. 92, No. 5, 2004. Nisisako, T., Torii, T., Higuchi, T., “Formation of liquid droplets in a microchannel network for microreactor applications,” Sensor Symposium, Vol. 19, 2002, pp. 131-134. Situma, C., Hashimoto, M. and Soper, S. A., “Merging microfluidics with microarray-based bioassays,” Biomolecular Engineering, Vol. 23, 2006, pp. 213-231. Song, H., Bringer, M. R., Tice, J. D., Gerdts, C. J. and Ismagilov, R. F., “Experimental test of scaling of mixing by chaotic advection in droplets moving through microfluidic channels,” Appl. Phys. Lett., Vol. 83,No. 22, 2003, pp. 4664-4666. Seo, M., Paquet, C., Nie, Z., Xu, S. and Kumacheva, E., “Microfluidic consecutive flow-focusing droplet generatora,” Soft Matter, Vol. 3, 2007, pp. 986-992. Thorsen, T., Roberts, R. W., Arnold, F. H. and Quake, S. R., “Dynamic pattern formation in a vesicle-generating microfluidic device,” Physical Review Letters, Vol. 86, 2001, pp. 4163-4166. Tice, J. D., Song, H., Lyon, A. D. and Ismagilov, R. F., “Formation of droplets and mixing in multiphase microfluidics at low values of the reynolds and the capillary numbers,” Langmuir, Vol. 19, 2003, pp. 9127-9133. Tice, J. D., Lyon, A. D., Ismagilov, R. F., “Effects of viscosity on droplet formation and mixing in microfluidic channels,” Analytica Chimica Acta, Vol. 507, 2004, pp. 73-77. Tan, Y. C., Cristini, V., Lee, A. P., “Monodispersed microfluidic droplet generation by shear focusing microfluidic device,” Sensors and Actuators B, 2005. Tan, Y. C., Fisher, J. S., Lee, A. I., Cristini, V. and Lee, A. P., “Design of microfluidic channel geometries for the control of droplet volume, chemical concentration, and sorting,” Lab on a Chip, Vol. 4, 2004, pp. 292-298. Wang, W., Li, Z. X., Luo, R., Lu, S. H., Xu, A. D. and Yang, Y. J., “Droplet-based micro oscillating-flow PCR chip,” J. Micromech. Microeng, Vol. 15, 2005, pp. 1369-1377. Zheng, B., Tice, J. D. and Ismagilov, R. F., “Formation of droplets of alternating composition in microfluidic channels and applications to indexing of concentrations in droplet-based assays,” Analytical Chemistry, Vol. 76, No. 17, pp. 4977-4982. Zheng, B., Tice, J. D. and Ismagilov, R. F., “Formation of arrayed droplets by soft lithography and two-phase fluid flow, and application in protein crystallization,” Adv. Mater., Vol. 16, 2004, pp. 1365-1368. 林明甲, 電泳微流道之模擬與分析運用, 大葉大學碩士論文, 2004.
摘要: 
摘要
本研究設計一微流道晶片來生成乳化液滴,並利用可視化機制來觀察T型匯流處液滴生成的情形,以實驗的方法來探討毛細係數與兩相流流率比及液滴尺寸間的變化關係。實驗的內容共分三個部份:第一為固定消散相流流率,改變連續相流流率來進行實驗,實驗所得的變化趨勢呈現接近反比的關係。第二為固定連續相流流率,改變消散相流流率來進行實驗,實驗所得的變化趨勢呈現接近正比的關係。第三為固定消散相流與連續相流的流率及消散相流流道寬,改變連續相流流道寬來進行實驗,實驗結果顯示連續相流流道越寬,所生成液滴其尺寸越大。除了控制液滴尺寸之外,對於其生成的頻率也進行了相關的探討。
此技術平台所生成的乳化液滴,可控制其粒徑在100μm~600μm之間,粒徑大小平均誤差率在3﹪以內,代表其均勻性相當均一。未來可將此技術平台拓展至藥物輸送、生醫檢測及化學合成等領域。

Abstract
This study examines the emulsification of oil-in-water microdroplet in the microfluidics with a T-junction. The flow visualization technique was adopted to observe the dependence of droplet size and generation frequency upon the dispersed and continuous phase flow rates as well as the channel dimension. The microflidics allows one to control the size of droplet emulsion from 100 to 600 μm in diameter with a mean percentage error less than 3%. It is found that the droplet size increases with increasing dispersed phase flow rate but decreases with increasing continuous phase flow rate. It is also found that a wider continuous channel can generate larger droplet. As a result, the droplet size decreases with increasing capillary number and increases with increasing ratio of the dispersed and continuous phase flow rates. On the other hand, the droplet generation frequency decreases with increasing ratio of the dispersed and continuous phase flow rates.
URI: http://hdl.handle.net/11455/2175
其他識別: U0005-2708200813291500
Appears in Collections:機械工程學系所

Show full item record
 

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.