Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/2290
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dc.contributor郭正雄zh_TW
dc.contributor游明輝zh_TW
dc.contributor.advisor陳志敏zh_TW
dc.contributor.author黃韋翔zh_TW
dc.contributor.authorHuang, Wei-Hsiangen_US
dc.contributor.other中興大學zh_TW
dc.date2010zh_TW
dc.date.accessioned2014-06-05T11:42:53Z-
dc.date.available2014-06-05T11:42:53Z-
dc.identifierU0005-1908200912184500zh_TW
dc.identifier.citationBhagat A. A. S. , Kuntaegowdanahalli S. S. , Papautsky I. , “Continuous particle separation in spiral microchannels using dean flows and differential migration,” Lab Chip, Vol. 8, 2008, pp. 1906-1914. Choi S. , Song S. , Choi C. , Park J.K. , “Continuous blood cell separation by hydrophoretic filtration,” Lab Chip, Vol. 7, 2007, pp. 1532-1538. Haeberle S. , Brenner T. , Zengerle R. , Ducree J. , “Centrifugal extraction of plasma from whole blood on a rotating disk,” Lab Chip, Vol. 6, 2006, pp. 776-781. Hau W. L. W. , Liu Z. , Korvink J. , Zengerle R. , Ducree J. , “Near-wall velocity of suspended particles in microchannel flow,” Proceedings of MEMS 2008, Tucson, AZ, USA, January 13-17, 2008, pp. 633-636. Lazar I. M. , Trisiripisal P. , Sarvaiya H. A. , “Microfluidic liquid chromatography system for proteomic applications and biomarker screening,” Analytical Chemistry, Vol. 78, No. 15, 2006, pp. 5513-5524. Matas J. P. , Morris J. F. , Guazzelli E. , “Lateral forces on a sphere,” Oil & Gas Science and Technology - Rev. IFP, Vol. 59, No. 1, 2004, pp. 59-70. Pamme N. , “Continuous flow separations in microfluidic devices,” Lab Chip, Vol. 7, 2007, pp. 1644-1659. Shevkoplyas S. S. , Yoshida T. , Munn L. L. , Bitensky M. W. , “Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device,” Analytical Chemistry, Vol. 77, No. 3, 2005, pp. 933-937. White F. M. , “Vicous fluid flow,” McGraw-Hill, 1974, pp. 123-124. Yamada M. , Seki M. , “Hydrodynamic filtration for on-chip particle concentration and classification utilizing microfluidics,” Lab Chip, Vol. 5, 2005, pp. 1233-1239. Zhang C. X. , Manz A. , “High-speed free-flow electrophoresis on chip,” Analytical Chemistry, Vol. 75, No. 21, 2003, pp. 5759-5766.zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/2290-
dc.description.abstract本研究以流阻網路系統觀念設計及製作梳狀微流道利用cross-flow filtration分離微型顆粒。梳狀微流道晶片有兩個入口,一個注入顆粒溶液,另一個注入Tween 20水溶液,目的是要使溶液中的顆粒得以集中於主流道的側壁面,提升分離效果。我們使用PDMS作為晶片材料,製作兩種T型入口方式晶片,以顆粒入口流道相對於梳狀分歧流道的位置區分,一種為垂直式,另一種為平行式。實驗晶片的流道深度為23 μm、主流道寬度為30 μm、梳狀分支流道由50 μm與70 μm兩種寬度組成,梳狀流道數量為11條。分離的顆粒直徑為3 μm與10 μm,單位體積的顆粒數量分別為3.4×103 /μL與1.8×102 /μL。本實驗的入口流率Q0為45 μL/min與60 μL/min,為了配合梳狀流道數量,顆粒溶液與Tween 20水溶液的流率比固定為1:2,並利用螢光顯微鏡搭配CCD攝影機觀察與記錄顆粒分離的情形。實驗結果發現平行式的分離效果優於垂直式,主要是垂直式入口流道的顆粒溶液於主流道的流場分佈呈現中間凹陷兩側突起的情形,此現象會隨著流率增加而變得明顯,導致顆粒不能集中於主流道側壁面,在較高流率Q0 = 60 μL/min時無法完全分離顆粒。平行式入口流道顆粒溶液的流場分佈呈現中間微凸的情形,但受流量的影響不大,在本實驗使用的流率,皆可以成功分離顆粒。zh_TW
dc.description.tableofcontents摘要 ......................................................i Abstract..................................................ii 目錄 ......................................................v 表目錄 ...................................................vi 圖目錄 ...................................................vi 符號表 .................................................viii 第一章 緒論 ..............................................1 1.1 研究動機 ..............................................1 1.2 文獻回顧 .............................................2 1.3 研究目的 ..............................................4 1.4 論文架構 ..............................................5 第二章 理論基礎與晶片設計 .................................6 2.1 晶片運作原理 ..........................................6 2.2 晶片設計 ..............................................8 第三章 實驗晶片製作 ......................................12 3.1 微影製程 .............................................13 3.2 PDMS微流體晶片製作 ...................................16 3.3 晶片接合(Bonding) ....................................17 3.4 微流道幾何尺寸量測 ...................................18 第四章 實驗設備 .........................................19 4.1 螢光顯微鏡 ...........................................19 4.2 影像擷取系統 .........................................20 4.3 注射式幫浦 ...........................................21 第五章 實驗結果與討論 ...................................22 5.1 實驗流體選用 .........................................22 5.2 進口匯集處模擬結果 ...................................24 5.3 垂直式顆粒入口流道實驗 ...............................26 5.3.1 Q0 = 45 μL/min (Qp = 15 μL/min、Qw = 30 μL/min) .27 5.3.2 Q0 = 60 μL/min (Qp = 20 μL/min、Qw = 40 μL/min) .27 5.4 平行式顆粒入口流道實驗 ...............................30 5.4.1 Q0 = 45 μL/min (Qp = 15 μL/min、Qw = 30 μL/min) .31 5.4.2 Q0 = 60 μL/min (Qp = 20 μL/min、Qw = 40 μL/min) .31 5.5 討論 .................................................34 第六章 結論與建議 .......................................35 參考文獻 .................................................37 附錄A 理論基礎與設計方法 .................................39 A.1 顆粒分離基本原理 .....................................39 A.2 分離區流道設計方法 ...................................41 A.2.1 β值推導 ...........................................43 A.2.2 流量推導 ...........................................45 A.2.3 分支流道的流阻(Rb)推導 .............................46 A.2.4 分支流道的長度 .....................................48 A.2.5 歸納整理 ...........................................50 A.3 實驗晶片分離區流道設計 ...............................51 附錄B 流阻公式推導 ..................................55zh_TW
dc.language.isoen_USzh_TW
dc.publisher機械工程學系所zh_TW
dc.relation.urihttp://www.airitilibrary.com/Publication/alDetailedMesh1?DocID=U0005-1908200912184500en_US
dc.subjectcomb-like microchannelsen_US
dc.subject梳狀微流道zh_TW
dc.subjectmicroparticleen_US
dc.subjectcross-flow filtrationen_US
dc.subject微顆粒zh_TW
dc.subject橫向流分離zh_TW
dc.title梳狀微流道內微顆粒分離實驗zh_TW
dc.titleContinuous size separation of particles in comb-like microchannelsen_US
dc.typeThesis and Dissertationzh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.openairetypeThesis and Dissertation-
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
Appears in Collections:機械工程學系所
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