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標題: 植基於細胞自動機與RFID之基因密碼辨識與管理資訊系統-以miRNA為例
Genetic Code Management Systems based on Cellular Automata and RFID- Cases Study in miRNA
作者: 吳協昌
Wu, Hsieh-Chung
關鍵字: 細胞自動機;DNA barcode;基因條碼;miRNA;RFID;cellular automata;RFID;miRNA
出版社: 資訊管理學系所
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"MiRNA-9 inhibits ovarian cancer cell growth through regulation of NF-kappaB1." FEBS J 276(19): 5537-5546. [14]Hajibabaei, M., G. A. Singer, et al. (2007). "DNA barcoding: how it complements taxonomy, molecular phylogenetics and population genetics." Trends Genet 23(4): 167-172. [15]Hamori, E. and J. Ruskin (1983). "H curves, a novel method of representation of nucleotide series especially suited for long DNA sequences." J Biol Chem 258(2): 1318-1327. [16]Hebert, P. D. N., A. Cywinska, et al. (2003). "Biological identifications through DNA barcodes." Proceedings of the Royal Society of London. Series B: Biological Sciences 270(1512): 313-321. [17]Hu, X., D. M. Macdonald, et al. (2009). "A miR-200 miRNA cluster as prognostic marker in advanced ovarian cancer." Gynecol Oncol 114(3): 457-464. [18]Huang, J., Q. Xu, et al. (2007). "Identifying earthworms through DNA barcodes." Pedobiologia 51(4): 301-309. [19]Iorio, M. V., R. Visone, et al. (2007). "MiRNA signatures in human ovarian cancer." Cancer Res 67(18): 8699-8707. [20]Jiang, Q., Y. Wang, et al. (2009). "miR2Disease: a manually curated database for miRNA deregulation in human disease." Nucleic Acids Research 37(suppl 1): D98-D104. [21]Klonoff, D. C. (2008). "Designing an artificial pancreas system to be compatible with other medical devices." J Diabetes Sci Technol 2(5): 741-745. [22]Kumagai, M. H. and P. Miller (2006). "Development of electronic barcodes for use in plant pathology and functional genomics." Plant Mol Biol 61(3): 515-523. [23]K. W. Church and J. I. Helfman, "Dotplot: A Program for Exploring Self-Similarity in Millions of Lines of Text and Code," Journal of Computational and Graphical Statistics, vol. 2, pp. 153-174, 1993. [24]Laios, A., S. O''Toole, et al. (2008). "Potential role of miR-9 and miR-223 in recurrent ovarian cancer." Mol Cancer 7: 35. [25]Mun, I. K., A. B. Kantrowitz, et al. (2007). Active RFID System Augmented With 2D Barcode for Asset Management in a Hospital Setting. RFID, 2007. IEEE International Conference on. [26]Nam, E. J., H. Yoon, et al. (2008). "MiRNA Expression Profiles in Serous Ovarian Carcinoma." Clinical Cancer Research 14(9): 2690-2695. [27]Park, S. M., S. Shell, et al. (2007). "Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2." Cell Cycle 6(21): 2585-2590. [28]Shell, S., S. M. Park, et al. (2007). "Let-7 expression defines two differentiation stages of cancer." Proc Natl Acad Sci U S A 104(27): 11400-11405. [29]A. Williams, et al., "Graphic Representations of Amino Acid Sequences," in Visualizing biological information, C. A. Pickover, Ed., ed Singapore: World Scientific Publishing Co. Pre. Ltd., 1995. [30]Wong, E. H. K. and R. H. Hanner (2008). "DNA barcoding detects market substitution in North American seafood." Food Research International 41(8): 828-837. [31]Wienholds, E. and R. H. Plasterk (2005). "MicroRNA function in animal development." FEBS Lett 579(26): 5911-5922. [32]Xiao, X., S. Shao, et al. (2005). "Using cellular automata to generate image representation for biological sequences." Amino Acids 28(1): 29-35. [33]Yang, H., W. Kong, et al. (2008). "MiRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN." Cancer Res 68(2): 425-433. [34]Zhang, L., S. Volinia, et al. (2008). "Genomic and epigenetic alterations deregulate miRNA expression in human epithelial ovarian cancer." Proc Natl Acad Sci U S A 105(19): 7004-7009.
近年來,隨著人們對生物多樣性的重視,世界各地為保存生物的多樣性開始收集各種生物的基因序列,隨著序列的收集增加,許多科學家開始思考著如何資訊化或運用這些基因序列,2003年,加拿大的學者Paul Hebert提出了利用基因序列來當作物種辨識的條碼(DNA barcode),基因條碼(DNA barcode)提供了一種新的辨識物種方法,相較於過去傳統分類的耗時耗力,基因條碼能更快速的辨識物種,目前更運用在許多的地方,舉凡辨識未知的物種、觀察動物的生態,物種分類等,基於此概念,本研究使用了基因條碼來做為研究,由於基因條碼使用的基因序列長度都相當的長,而且有時需要好幾個基因序列片段才能辨識出一物種。因此本研究使用了片段較短且功能明顯的miRNA序列來做處理,經由細胞自動機方法來轉換序列,並將序列轉換成圖像,轉換出的miRNA圖像除了可直接藉由肉眼觀察序列間的相同相異部分外,本研究中還觀察出調控相同卵巢癌基因的miRNA序列有其共通性,未來可將收集這些相關的序列圖形建立資料庫,結合RFID與後端的miRNA資料庫,形成一基於RFID的 miRNA條碼辨識系統,用在自動的條碼辨識上。

In recently years, Biodiversity is become an important issue in the world. Many Biologists are interested in collecting DNA sequences in order to use in the future.
In 2003, Paul Hebert provided an idea about DNA barcode. DNA barcode use DNA sequences to distinguish different species. It is useful and fast than traditional methods, but sometime it need more than one DNA sequences to distinguish species.
In this study, a new DNA barcode system combine with RFID which is based on miRNA is presented. This system uses cellular automata(CA) theory to translate miRNA sequences to images. By using images as DNA barcode to distinguish different miRNA and collecting images to build database. The research result shows that regulated the affect ovarian cancer gene’s miRNA sequences images has common fragment. This research also create a system combined miRNA images database and RFID. The system can use RFID to distinguish miRNA images quickly and use miRNA images to distinguish sequences differently.
其他識別: U0005-2007201215301400
Appears in Collections:資訊管理學系

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