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標題: 精密加工技術於質譜儀新式電噴灑頭之製造應用
The Fabrication and Application of New Mass Spectrometry Electro-spray Tip Based on the Precisely Mechanical Micro Machining
作者: 楊慕文
Yang, MuWen
關鍵字: electro-spray tip;電噴灑噴嘴
出版社: 機械工程學系

The combination of electro-spray tip and mass spectrometry can effectively distinguishing the compositions of the examining sample. The analytical capability of the electro-spray tip plays the key role to the quality of the distinguishing results.
In general, the electro-spray tip in use can be categorized into two groups, the fused-silica capillary chip and the planar-edge chip. The main drawback of the planar-edge chip is that the side area of the channel exit is large enough such that the stability of the Taylor cone is affected by the moist at the channel exit and its inducing big droplet. The fused-silica capillary chip was developed to reduce the area at the side surface of the planar-edge chip. However, the dead volume will decrease the separating resolution.
In order to solve these problems, two new types of electro-spray tips are designed and fabricated by precisely mechanical micro machining. The first type is the high efficiency Taylor cone chip that is made of the hydrophobic poly-material. In this new chip, the degree of moist and the edge diffusion problems are suppressed through the scale down of the side surface. While the design concept of the dead volume free micro-channel chip is to insert a needle-like bar into the micro channel such that there is no redundant area inside the channel and the dead volume problem can be eliminated. Since the sample does not need to pass any redundant junction, the separating quality and resolution decline problems can be reduced.
Experimental results demonstrate that the proposed two new electro-spray tips possess the similar resolution and sensitivity as the conventional fused-silica capillary chip. However, the cost of our new chips is much lower than the conventional ones.
To precisely understand the dynamic spray characteristics of the electro-spray tip, the micro-fluidics theory is adopted to model the behavior of the tip. The dynamic model is verified through experiments.
In addition to the advantages aforementioned, the proposed chips require no extra modification of the equipment. It can be helpful to the researches and industry in the bio-chemical society.
Appears in Collections:機械工程學系所

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