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dc.contributorHou-Chien Changen_US
dc.contributor.authorLi, Yi-Chienen_US
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dc.description.abstract皮膚的角質層是藥物經皮傳輸系統發展中最主要的障礙,因此需要改進藥品的物化特性,藉以擾動角質層結構來增進藥物穿透效率。幾丁聚醣是一種經過去乙醯化的多醣體,其前驅物幾丁質是自然界中含量第二多的高分子。它具有良好的生物相容性、生物降解性及非抗原性,有利於醫療和製藥的應用。 本研究利用褐藻酸鈉與兩性幾丁聚醣交聯的水凝膠應用在藥物促滲劑和組織工程。實驗利用FT-IR和1H NMR確認其化學特性,其中冷凍乾燥的交聯支架利用SEM和拉力測試評估其應用在組織工程的可能性。根據SEM結果顯示,孔洞直徑約100~250 μm。 幾丁聚醣利用疏水性官能基 - 月桂酸和棕櫚酸完成架接,並評估此凝膠當做親水性藥物 - 間-苯二酚載體的經皮滲透效果。在體外經皮滲透實驗,利用垂直式經皮滲透儀進行監測並利用數學模型得知有效滲透係數。實驗配方分別為不加入幾丁聚醣的溶液為控制組,加入N-palmitoyl chitosan (PNC), N-lauryl chitosan (LNC), N-palmitoyl chitosan- alginate (PNC-A), N-lauryl chitosan- alginate (LNC-A)為比較組。根據結果,LNC具有當作藥物經皮滲透載體的潛力。zh_TW
dc.description.abstractBeing the major contributor of permeation resistance of transdermal drug delivery system(TDDS),stratum corneum (SC) has been the focus of TDDS research aiming at improving the efficiency of drug permeation through skin. One of the approaches toward that is to modify the physicochemical properties of the drug and thus alter the interaction between drug molecules and SC. Chitosan has received interest for medical and pharmaceutical applications due to its intrinsic properties including biocompatibility, biodegradability and non-antigenicity. In this work hydrogel solutions composed of cross-linked amphiphilic chitosan and alginate porous scaffold were prepared for the in vitro permeation experiments and tissue engineering. Experiments performed on the crosslinked scaffolds that physical properties were examined by SEM,and Tensile test(Young’s modulus),as well as its chemical identity was determined by FT-IR and confirmed by 1H NMR. The morphology results showed the pore size ranged from 100 to 250 μm. The purpose of this study is to evaluate the transdermal permeation enhancement of the modification of the water-soluble chitosan with pendant hydrophobic groups to achieve non-covalent cross-linking with fatty acid, and as well evaluate the potential of the amphiphilic hydrogels as topical delivery carrier for the hydrophilic model compound Resorcinol (Re). Results were analyzed with a numerical model to produce quantitative indexes for the evaluation of transdermal drug delivery efficiency. A family of chitosan derivatives including N-palmitoyl chitosan (PNC), N-lauryl chitosan (LNC), N-palmitoyl chitosan- alginate (PNC-A), N-lauryl chitosan- alginate (LNC-A) were employed as permeation enhancers. The results suggested LNC was a significant enhancer for transdermal permeation of Re.en_US
dc.description.tableofcontents摘要.....I Abstract.....II 目錄.....III 圖目錄.....V 表目錄.....VII 第一章 前言.....1 第二章 文獻回顧.....2 2.1 藥物經皮輸送系統.....2 2.2 皮膚構造.....3 2.3 經皮給藥途徑.....5 2.4 經皮滲透原理.....7 2.5 促進經皮吸收方法.....12 2.6 幾丁質與幾丁聚醣.....14 2.6.1 幾丁質.....14 2.6.2 幾丁聚醣.....15 2.6.3 幾丁聚醣在生醫上的應用.....17 2.6.4 物理性修飾.....18 2.6.5 化學性修飾.....18 2.7 褐藻酸鈉.....19 2.7.1 鈣對褐藻膠凝膠作用的影響.....20 2.7.2 褐藻酸鈉在生醫上的應用.....21 2.8 交聯材料.....21 2.8.1 兩性幾丁聚醣與褐藻酸鈉交聯材料.....22 2.9 劑型.....24 2.9.1 水凝膠簡介.....24 2.9.2 化學性水凝膠.....24 2.9.3 物理性水凝膠.....27 2.9.4 兩性幾丁聚醣凝膠.....28 2.10 組織工程.....30 2.11 藥品性質與用途.....32 間-苯二酚.....32 2.12 定量與定性分析.....32 第三章 實驗方法、藥品與儀器.....34 3.1 實驗方法.....34 3.2 實驗設計與架構.....37 3.3 兩性幾丁聚醣與褐藻酸納其交聯物物化性測試.....38 3.3.1 傅立葉轉換紅外光譜儀.....38 3.3.2 核磁共振光譜儀.....38 3.3.3 掃描式電子顯微鏡.....38 3.3.4 機械性質分析.....38 3.3.5 接觸角測試.....38 3.3.6 膨潤率.....38 3.3.7 藥物釋放測試.....39 3.4 體外經皮滲透實驗.....39 3.4.1 促滲劑配製.....41 3.4.2 皮膚樣品處理.....42 3.4.3 經皮滲透實驗步驟Franz Diffusion Cell.....42 3.4.4 HPLC分析方法.....43 3.4.5 解析模型擬合.....45 3.5 實驗藥品.....48 3.6 實驗儀器.....49 第四章 結果與討論.....50 4.1 兩性幾丁聚醣與褐藻酸鈉其交聯物物化性測試.....50 4.1.1 傅立葉轉換紅外光譜分析 .....50 4.1.2 核磁共振光譜分析.....56 4.1.3 掃描式電子顯微鏡觀察.....59 4.1.4 機械性質測試.....63 4.1.5 接觸角測試.....65 4.1.6 膨潤率測試.....67 4.1.7 藥物釋放測試.....69 4.2 體外經皮滲透實驗.....72 4.2.1 標準曲線.....72 4.2.2 藥物累積滲透量.....72 4.2.3 促滲劑對藥物滲透的影響 .....85 第五章 結論與未來展望.....88 參考文獻.....91zh_TW
dc.titleThe Evaluation of Feasibility on Modified Chitosan as Transdermal Drug Delivery Enhancer and Tissue Engineering Scaffolden_US
dc.typeThesis and Dissertationzh_TW
item.openairetypeThesis and Dissertation-
item.fulltextno fulltext-
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