Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/3114
標題: 磁性中空玻璃球製備、分析與維他命C釋放行為之研究
The Study of Preparation、Characterization and Release Behavior of Vitamin C of Magnetic Hollow Silica Spheres
作者: 陳新岳
Chen, Hsin-Yueh
關鍵字: 無乳化聚合;emulsifier-free polymerization;磁性奈米粒子;磁性中空玻璃;維他命C;釋放控制;magnetic nanoparticles;magnetic hollow glass sphere;ascorbic acid;control release
出版社: 化學工程學系所
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摘要: 
本實驗以無乳化聚合製備均一聚苯乙烯乳液,其粒徑約在400 nm間。接著添加親水性較高的壓克力酸(AA)接枝外殼,以提供羧基。由光散射粒徑分析儀(DLS)觀察,在壓克力酸改質PS乳液(PS-AA),發現其粒徑大小均一。接著,利用共沉澱法在水相溶液中合成具有磁性的四氧化三鐵奈米粒子,其晶體大小約為5-8 nm間。經由表面電位(Zeta-potential)測量PS-AA乳液及磁性奈米粒子之表面電位性質,由分析圖中可得知,壓克力酸改質PS乳液中於pH值在2-10間之表面電位皆帶負電位,而磁性奈米粒子之等電位點(Isoelectric Point, IEP)出現在pH值為6附近。實驗結果說明,調整溶液之pH值可使磁性奈米粒子吸附於壓克力酸改質PS球表面。當pH值在2-5間,因電位相異可有效的使磁性奈米粒子吸附於壓克力酸改質PS球表面。
藉由控制TEOS添加量,改變pH與反應條件形成PS-AA/Fe3O4 /SiO2核-殼結構;最後,再利用高溫煅燒將核心壓克力酸改質PS球移除,得到磁性中空玻璃球。透過穿透式電子顯微鏡(TEM)觀察表面型態,當煅燒後得到均一且完整的磁性中空玻璃球結構,平均粒徑在429.8 nm。經由磁性分析(VSM),從磁化曲線圖可得到磁性中空玻璃球的飽和磁化量為43.90 emu/g,且具有超順磁的性質。此外,經BET測量,磁性中空玻璃球在煅燒前後比表面積由4.11 m2/g增加至274.8 m2/g。
最後,將維他命C置於磁性中空玻璃球內,研究其釋放行為。將累積釋放百分比帶入零級模型、一級模型、Higuchi模型。其中,Higuchi模型中,第零小時到第三小時,反應釋放常數為64.76,第三小時到第
十小時,反應速率常數為2.40。

In this study, polystyrene latex was first prepared by emulsifier free polymerization of styrene in aqueous solution with the particles diameter about 400 nm. The PS latex was grafted with acrylic acid (AA) to impart their surface with carboxylic functional groups. The PS-AA latex particles are nearly monodispersed based on DLS data. Afterward, the Fe3O4 nanoparticles was synthesized by coprecipitation method with the particles diameter about 5-8 nm. Zeta-potential measurements were used to evaluate the surface charge of the PS-AA latex and Fe3O4. The Zeta-potential of the PS latex is negative between the pH range of 2-10. The isoelectric point (IEP) of the Fe3O4 nanoparticles appears at around pH 6. The experimental results indicate that Fe3O4 nanoparticles adsorb on the surface of PS-AA spheres. At low pH value (pH=2-4), the adsorption is effective due to opposite charges on the surface of the PS-AA latex and the magnetic nanoparticles.
The PS-AA/Fe3O4/SiO2 core-shell structure was performed by controlling the hydrolysis/condensation reaction of TEOS at various pHs and reaction conditions. Finally, a magnetic hollow silica spheres was obtained by removing PS-AA core by calcination step. Transmission electron microscopy (TEM) demonstrats that the obtained magnetic hollow silica nanospheres with the perfect spherical profile were well monodispersed and uniform with the mean diameter of 429.8 nm. The magnetic hollow silica nanospheres bear the characteristic of superparamagnetic with the saturation magnetization value of 43.90 emu/g by property VSM(Vibrating Sample Magnetometer). Moreover, the BET measurements show the surface area of 4.11 m2/g for silica spheres with magnetic peroperty and 274.48 m2/g for magnetic hollow silica sphere aftercalcination.
Finally, We also focused on the encapsulation of ascorbic acid into magnetic hollow silica and studied their controlled release behavior in the aqueous solution. Release data of Vitamin C were analyzed with zero order release model, the first order release model, and Higuchi release model. The release model fits well with the Higuchi model with the kinetic constant k1 equals 64.76 in the first 3 hours and 7.34 for k2 after 3 hours.
URI: http://hdl.handle.net/11455/3114
其他識別: U0005-2901201311501300
Appears in Collections:化學工程學系所

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