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標題: The Activity of Plasma Matrix Metalloproteinase-9 as a Marker to Reflect the Tissue Level of Mammary Glands Tumor in Dogs
作者: Shia, Wei-Yau
Liu, Shih-Ming
Lee, Chun-Sheng
Lin, Jian-Liang
Chou, Chih-Chung
Yuasa, Yumi
Chang, Shih-Chieh
Lee, Wei-Ming
關鍵字: dog;mammary tumor;matrix metalloproteinase;matrix-metalloproteinase (mmp)-2;cancer-patients;breast-cancer;mmp-9;activities;iv collagenase;gelatinase-a;metastasis;adenocarcinoma;expression;mechanisms
Project: Thai Journal of Veterinary Medicine, Volume 41, Issue 1, Page(s) 111-117.
In order to understand the change of MMP-2 and MMP-9 in dogs with mammary gland tumor (MGT), the activity of MMP-2 and MMP-9 in plasma samples, MGT tissues and near by normal mammary gland tissues were evaluated by gelatin zymography. The levels of MMP-2 and MMP-9 were significantly higher in tumor tissues than those in normal gland tissues (p<0.05). Plasma MMP-9 levels in malignant cases were higher than those in benign (p=0.15) and non-tumor cases (p<0.05). Likewise, plasma MMP-2 levels in malignant MGT cases were higher than non-tumor (p<0.01) and benign cases (p=0.54)). Furthermore, plasma MMP-9 levels were reflected and positively correlated with MMP-9 in tumor tissues (r=0.78, p=0.02), but not MMP-2. Our results indicated that the MMP-2 and MMP-9 levels are associated with tumor malignancy, and plasma MMP-9 activity can become a potential marker both in follow-up and prognosis of canine MGT patients.
ISSN: 0125-6491
Appears in Collections:獸醫學系所

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