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|標題:||Beneficial effects of yam on carbon tetrachloride-induced hepatic fibrosis in rats||作者:||Chan, Y.C.
|關鍵字:||lyophilised yam, liver fibrosis;CCI(4), rat;cell-proliferation;lipid-metabolism;dioscorea-alata;chinese-yam;flour diet;liver;antioxidant;silymarin;cirrhosis;mice||Project:||Journal of the Science of Food and Agriculture||期刊/報告no：:||Journal of the Science of Food and Agriculture, Volume 90, Issue 1, Page(s) 161-167.||摘要:||
BACKGROUND: In a previous study, lyophilised yam reduced brain amyloid beta-protein (A beta) accumulation and improved the antioxidative defence system in senescence-accelerated (SAMP8) mice. Therefore, the aim of this study was to investigate the hepatic protection of yam in the carbon tetrachloride-induced hepatic fibrosis of rats. Hepatic fibrosis was induced in rats via intraperitoneal injections Of CCI(4) at a dose of 1 mL kg(-1) body weight (BW) twice weekly for 8 weeks. Three groups of rats were gavaged daily with yams at doses of 0.5, 1 and 2 g kg(-1) BW for 8 weeks, respectively. RESULTS: Yam treatments significantly decreased the ratio of liver/body weight, levels of gamma-glutaminotranspeptidase (GGT), low-density lipoprotein, and triglyceride in serum when compared with those administered CCI(4) alone. Treatment with yams significantly elevated antioxidant activities of glutathione peroxidase (GSH-Px) and superoxidase dismutase (SOD) in livers. Microscopically, yam-treated groups presented with low histoscores Of CCI(4)-induced liver injury and fibrosis. Additionally, yam treatment reduced the area of GGT-positive foci and the index of proliferating cell nuclear antigen (PCNA) in liver. CONCLUSION: Daily administration of yam attenuates CCI(4)-induced hepatic fibrosis in rats in a dose-dependent manner; this attenuation may be related to the antioxidant properties of yams. (c) 2009 Society of Chemical Industry
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