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標題: Effects of dexamethasone on peripheral blood mononuclear cell phenotype in weanling piglets
作者: Lo, D.Y.
Lee, W.M.
Chien, M.S.
Lin, C.C.
Lee, W.C.
關鍵字: dexamethasone;lymphocyte phenotype;porcine;interferon-gamma;in-vivo;immune;stress;lymphocytes;cortisol;invivo;glucocorticoids;performance;mechanisms
Project: Comparative Immunology Microbiology and Infectious Diseases
期刊/報告no:: Comparative Immunology Microbiology and Infectious Diseases, Volume 28, Issue 4, Page(s) 251-258.
The aim of this study was to evaluate the effect of dexamethasone treatment on the immune system of weanling piglets. Piglets were administered dexamethasone (DEX; 1 mg/kg, IM) every 12 h for 2 consecutive days (short-term experiment) or DEX (1 mg/kg, IM) daily for 2 weeks (long-term experiment). The relative percentage of CD8(+) T cells in peripheral blood mononuclear cells (PBMCs) was significantly decreased (P < 0.05) in both short- and long-term DEX-treated groups compared to their control groups. The percentage of IgM(+) cells in PBMCs of the long-term DEX-treated group was greatly increased (P < 0.05) in comparison to the control group. The results of this study indicate that short-term DEX-treatment increases leucocyte function; however, long-term DEX-treatment depresses leucocyte function, especially that of CD8(+) T cells. (c) 2005 Elsevier Ltd. All rights reserved.
ISSN: 0147-9571
DOI: 10.1016/j.cimid.2005.03.001
Appears in Collections:獸醫學系所

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