Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32686
DC FieldValueLanguage
dc.contributor.authorLin, K.L.en_US
dc.contributor.author何素鵬zh_TW
dc.contributor.authorYang, D.Y.en_US
dc.contributor.authorChu, I.M.en_US
dc.contributor.authorCheng, F.C.en_US
dc.contributor.authorChen, C.J.en_US
dc.contributor.authorHo, S.P.en_US
dc.contributor.authorPan, H.C.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T07:44:06Z-
dc.date.available2014-06-06T07:44:06Z-
dc.identifier.issn0022-4804zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/32686-
dc.description.abstractBackground. Anastomosis of the nerve especially at narrow surgical field and presence of surgical tension is not easily accessible. DuraSeal demonstrates strong adhesive power without producing neurotoxicity. Herein, we evaluate the possibility of DuraSeal as a substitute in the repair of sciatic nerve gap injury. Materials and Methods. The nerve gap model was constructed by excising the sciatic nerve (5 mm in length) in Sprague Dawley rats leaving a 5 mm nerve defect between nerve stumps. Animals were categorized into four groups: Group I: no treatment; Group II: 4 stitches suture; Group III: nerve approximation fixed by tissue glue; Group IV: nerve approximation fixed by DuraSeal. The motor function assessment included the CatWalk and SFI as well as electrophysiological studies. Nerve continuity and regeneration was examined at 1 and 8 wk after injury. The inflammatory cells, Schwann cell apoptosis, and Schwann cell proliferation were also investigated 1 wk after injury. Results. The achievement of nerve continuity and myelination by DuraSeal approached that of suture demonstrated by crystal violet and Luxol Fast Blue staining at 1 and 8 wk, respectively. Motor function and electrophysiological parameters were restored in DuraSeal and suture group. Early expression of neurofilament and bromodeoxyuridine (BrdU) was also observed in these two groups. There was no statistically significant difference in deposits of macrophages and neutrophil cells or cell apoptosis among these four groups. Conclusions. DuraSeal achieved the same nerve regeneration compared with that of suture and produced better regeneration than that of the tissue glue or without any treatment. The accomplishment of nerve regeneration and continuity without causing neurotoxicity justifies using DuraSeal as a ligature in the anastomosis of nerve gap injury. (C) 2010 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Surgical Researchen_US
dc.relation.ispartofseriesJournal of Surgical Research, Volume 161, Issue 1, Page(s) 101-110.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.jss.2008.10.020en_US
dc.subjectsciatic nerve injuryen_US
dc.subjectperipheral nerve regenerationen_US
dc.subjecttissue glueen_US
dc.subjectsutureen_US
dc.subjectDuraSealen_US
dc.subjectCatWalken_US
dc.subjectbrachial-plexus injuryen_US
dc.subjectcatwalk gait analysisen_US
dc.subjectfunctional recoveryen_US
dc.subjectfibrin glueen_US
dc.subjectin-vitroen_US
dc.subjectregenerationen_US
dc.subjectrepairen_US
dc.subjectadhesivesen_US
dc.subjectlesionsen_US
dc.subjectalphaen_US
dc.titleDuraSeal as a Ligature in the Anastomosis of Rat Sciatic Nerve Gap Injuryen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.jss.2008.10.020zh_TW
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:獸醫學系所
Show simple item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.