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標題: Pharmacokinetic and depletion studies of sarafloxacin after oral administration to eel (Anguilla anguilla)
作者: Ho, S.P.
Cheng, C.F.
Wang, W.S.
關鍵字: eel;fish;HPLC;pharmacokinetics;sarafloxacin;salmon salmo-salar;atlantic salmon;rainbow-trout;aeromonas-salmonicida;scophthalmus-maximus;c-14 sarafloxacin;african;catfish;oxolinic acid;sea-water;fish
Project: Journal of Veterinary Medical Science
期刊/報告no:: Journal of Veterinary Medical Science, Volume 61, Issue 5, Page(s) 459-463.
The pharmacokinetics of sarafloxacin applied by oral gavage at a dose of 15 mg/kg b.w. was studied in eel (Anguilla anguilla) at water temperature of 24 degrees C. Sarafloxacin levels were determined using high performance liquid chromatography with a quantitation limit of 0.07 mu g/ml or gram. The time to peak plasma concentration, T-max, was 12 hr and peak concentration, C-max, was 2.64 mu g/ml. The absorption rate constant (k(a)) was 0.23 hr(-1) (r=0.996). The drug disposition curve after T-max was fitted to a two-compartment open model. The distribution rate constant (alpha) was 0.085 hr(-1) (r=0.972), and the half-life (t(1/2 alpha)) was 8.15 hr. The elimination rate constant (beta) was 0.023 hr(-1) (r=0.909), and the half-life (t(1/2 beta), was 30.13 hr. The estimated area under the curve, AUG, was 56.7 mu The peak concentrations of drug in liver, kidney, muscle, and skin were 13.39 (12 hr), 5.53 (12 hr), 1.82 (24 hr), and 0.78 mu g/g (40 hr), respectively. The time for sarafloxacin mean levels to fall below detectable limits in the plasma, muscle, and skin were 7 days but for the liver and kidney were 14 days.
ISSN: 0916-7250
DOI: 10.1292/jvms.61.459
Appears in Collections:獸醫學系所

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