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|標題:||Pharmacokinetic and depletion studies of sarafloxacin after oral administration to eel (Anguilla anguilla)||作者:||Ho, S.P.
|關鍵字:||eel;fish;HPLC;pharmacokinetics;sarafloxacin;salmon salmo-salar;atlantic salmon;rainbow-trout;aeromonas-salmonicida;scophthalmus-maximus;c-14 sarafloxacin;african;catfish;oxolinic acid;sea-water;fish||Project:||Journal of Veterinary Medical Science||期刊/報告no：:||Journal of Veterinary Medical Science, Volume 61, Issue 5, Page(s) 459-463.||摘要:||
The pharmacokinetics of sarafloxacin applied by oral gavage at a dose of 15 mg/kg b.w. was studied in eel (Anguilla anguilla) at water temperature of 24 degrees C. Sarafloxacin levels were determined using high performance liquid chromatography with a quantitation limit of 0.07 mu g/ml or gram. The time to peak plasma concentration, T-max, was 12 hr and peak concentration, C-max, was 2.64 mu g/ml. The absorption rate constant (k(a)) was 0.23 hr(-1) (r=0.996). The drug disposition curve after T-max was fitted to a two-compartment open model. The distribution rate constant (alpha) was 0.085 hr(-1) (r=0.972), and the half-life (t(1/2 alpha)) was 8.15 hr. The elimination rate constant (beta) was 0.023 hr(-1) (r=0.909), and the half-life (t(1/2 beta), was 30.13 hr. The estimated area under the curve, AUG, was 56.7 mu g.hr/ml. The peak concentrations of drug in liver, kidney, muscle, and skin were 13.39 (12 hr), 5.53 (12 hr), 1.82 (24 hr), and 0.78 mu g/g (40 hr), respectively. The time for sarafloxacin mean levels to fall below detectable limits in the plasma, muscle, and skin were 7 days but for the liver and kidney were 14 days.
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