Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32706
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dc.contributor.authorPan, H.C.en_US
dc.contributor.author何素鵬zh_TW
dc.contributor.authorCheng, F.C.en_US
dc.contributor.authorChen, C.J.en_US
dc.contributor.authorLai, S.Z.en_US
dc.contributor.authorLiu, M.J.en_US
dc.contributor.authorChang, M.H.en_US
dc.contributor.authorWang, Y.C.en_US
dc.contributor.authorYang, D.Y.en_US
dc.contributor.authorHo, S.P.en_US
dc.date2009zh_TW
dc.date.accessioned2014-06-06T07:44:07Z-
dc.date.available2014-06-06T07:44:07Z-
dc.identifier.issn0161-6412zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/32706-
dc.description.abstractClearance of fibrin and associated inflammatory cytokines by tissue-type plasminogen activator (t-PA) is related to improved regeneration in neurological disorder. The biological activity of fermented soybean (natto) is very similar to that of t-PA. We investigated the effect of the dietary supplement of natto on peripheral nerve regeneration. The peripheral nerve injury was produced by crushing the left sciatic nerve with a vessel clamp in Sprague-Dawley rats. The injured animals were fed orally either with saline or natto (16 mg/day) for seven consecutive days after injury. Increased functional outcome such as sciatic nerve functional index, angle of ankle, compound muscle action potential and conduction latency were observed in natto-treated group. Histological examination demonstrated that natto treatment improved injury-induced vacuole formation, S-100 and vessel immunoreactivities and axon loss. Oral intake of natto prolonged prothrombin time and reduced fibrinogen but did not change activated partial thromboplastin time and bleeding time. Furthermore, natto decreased injury-induced fibrin deposition, indicating a tolerant fibrinolytic activity. The treatment of natto significantly improved injury-induced disruption of blood - nerve barrier and loss of matrix component such as laminin and fibronectin. Sciatic nerve crush injury induced elevation of tumor necrosis factor alpha (TNF-alpha) production and caused apoptosis. The increased production of TNF-alpha and apoptosis were attenuated by natto treatment. These findings indicate that oral intake of natto has the potential to augment regeneration in peripheral nerve injury, possibly mediated by the clearance of fibrin and decreased production of TNF-alpha. [Neurol Res 2009;31:441-452]en_US
dc.language.isoen_USzh_TW
dc.relationNeurological Researchen_US
dc.relation.ispartofseriesNeurological Research, Volume 31, Issue 5, Page(s) 441-452.en_US
dc.relation.urihttp://dx.doi.org/10.1179/174313209x403878en_US
dc.subjectFermented soybeanen_US
dc.subjectnattoen_US
dc.subjectnerve crush injuryen_US
dc.subjectinflammatory cytokinesen_US
dc.subjectnerve regenerationen_US
dc.subjectfibrinen_US
dc.subjectextracellular matrixen_US
dc.subjectnecrosis-factor-alphaen_US
dc.subjectfibrinolytic enzyme nattokinaseen_US
dc.subjectschwann-cellen_US
dc.subjectdifferentiationen_US
dc.subjectvegetable cheese nattoen_US
dc.subjectperipheral-nerveen_US
dc.subjectneurotrophicen_US
dc.subjectfactorsen_US
dc.subjectwallerian degenerationen_US
dc.subjectinflammatory mediatorsen_US
dc.subjectfunctionalen_US
dc.subjectrecoveryen_US
dc.subjectup-regulationen_US
dc.titleDietary supplement with fermented soybeans, natto, improved the neurobehavioral deficits after sciatic nerve injury in ratsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1179/174313209x403878zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
Appears in Collections:獸醫學系所
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