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標題: Potential of using boric acid as a boron drug for boron neutron capture therapy for osteosarcoma
作者: Hsu, C.F.
Lin, S.Y.
Peir, J.J.
Liao, J.W.
Lin, Y.C.
Chou, F.I.
關鍵字: Osteosarcoma;BNCT;UMR-106 cell;Boric acid;in-vitro;accumulation
Project: Applied Radiation and Isotopes
期刊/報告no:: Applied Radiation and Isotopes, Volume 69, Issue 12, Page(s) 1782-1785.
Osteosarcoma is a malignant tumor commonly found in human and animals. The ability of boric acid (BA) to accumulate in osteosarcoma due to the mechanism of the bone formation of cancer cells would make boron neutron capture therapy (BNCT) an alternative therapy for osteosarcoma. This study evaluated the feasibility of using BA as the boron drug for BNCT of bone cancer. The cytotoxicity of BA to L929 cells exceeded that of UMR-106 cells. With 25 mu g (10)B/mL medium of BA treatment, the boron concentration in UMR-106 cells was higher than that in L929 cells. The biodistribution and pharmacokinetics of BA in Sprague-Dawley (SD) rats were studied by administrating 25 mg (10)B/kg body weight to SD rats. Blood boron level decreased rapidly within one hour after BA injection. Boron concentration in the long bone was 4-6 time higher than that of blood. Results of this study suggest that BA may be a potential drug for BNCT for osteosarcoma. (C) 2011 Elsevier Ltd. All rights reserved.
ISSN: 0969-8043
DOI: 10.1016/j.apradiso.2011.03.003
Appears in Collections:獸醫學系所

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