Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32866
DC FieldValueLanguage
dc.contributor.authorChang, Y.C.en_US
dc.contributor.author張登欽zh_TW
dc.contributor.authorHuang, Y.W.en_US
dc.contributor.authorChiang, K.H.en_US
dc.contributor.authorYang, T.C.en_US
dc.contributor.authorChung, T.C.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T07:44:19Z-
dc.date.available2014-06-06T07:44:19Z-
dc.identifier.issn0934-9723zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/32866-
dc.description.abstractExpression of the L1 and L2 beta-lactamase genes is generally regulated by a LysR type regulator of the AmpR in Stenotrophomonas maltophilia. The ampR gene is located immediately upstream of L2 and is transcribed divergently, forming an ampR-L2 module. The ampR-L2 modules of 16 S. maltophilia isolates were analyzed, revealing that the ampR-L2 intergenic (IG) regions show a significant genetic diversity, whereas AmpR proteins are highly conserved. The induction potential of the different AmpR toward the different ampR-L2 IG regions was evaluated by introducing the various IG-xylE transcriptional fusion constructs into a wild S. maltophilia strain. The induction levels achieved in the various AmpR-IG pairs display quantitative differences; meanwhile, the host beta-lactamase activity, in some cases, is attenuated by the introduced IG segment. Similar beta-lactamase attenuation phenomenon was observed in Enterobacter cloacae with an ampR-L2 IG segment of S. maltophilia. A concept of oligonucleotides attenuator for the development of an antimicrobial agent is proposed.en_US
dc.language.isoen_USzh_TW
dc.relationEuropean Journal of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.ispartofseriesEuropean Journal of Clinical Microbiology & Infectious Diseases, Volume 29, Issue 7, Page(s) 887-890.en_US
dc.relation.urihttp://dx.doi.org/10.1007/s10096-010-0924-0en_US
dc.subjectinductionen_US
dc.subjectregulatoren_US
dc.subjectgeneen_US
dc.subjectl1en_US
dc.titleIntroduction of an AmpR-L2 intergenic segment attenuates the induced beta-lactamase activity of Stenotrophomonas maltophiliaen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1007/s10096-010-0924-0zh_TW
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:獸醫學系所
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