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|標題:||Co-exposure of lipopolysaccharide and pseudomonas aeruginosa exotoxin A-induced multiple organ injury in rats||作者:||Chiu, C.C.
|關鍵字:||Cytokines;lipopolysaccharide;multiple organ injury;pseudomonas;aeruginosa exotoxin A;necrosis-factor-alpha;gadolinium chloride;kupffer cells;liver-injury;in-vivo;b-1 hepatotoxicity;mice;apoptosis;endotoxin;posttreatment||Project:||Immunopharmacology and Immunotoxicology||期刊/報告no：:||Immunopharmacology and Immunotoxicology, Volume 31, Issue 1, Page(s) 75-82.||摘要:||
Pseudomonas aeruginosa Exotoxin A (PEA) induces hepatotoxicity in experimental animals. Lipopolysaccharide (LPS) interacts synergistically with xenotoxics to induce severe organ injury. We examined the combination of non-injurious doses of LPS and sub-hepatotoxic PEA in the induction of multiple organ injury (MOI). Rats treated with 20 or 40 g/kg LPS plus 10 g/kg PEA developed severe liver, kidney, and lung injury; elevation of TNF-, IFN-, and IL-2; and high mortality. Depletion of Kupffer cells or T-cells by pretreatment with Gadolinium Chloride or FK506, respectively, attenuated MOI. Thus LPS + PEA acted synergistically on Kupffer and T-cells to induce proinflammatory cytokines contributing to MOI.
|Appears in Collections:||獸醫學系所|
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