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標題: Co-exposure of lipopolysaccharide and pseudomonas aeruginosa exotoxin A-induced multiple organ injury in rats
作者: Chiu, C.C.
Huang, Y.T.
Chuang, H.L.
Chen, H.H.C.
Chung, T.C.
關鍵字: Cytokines;lipopolysaccharide;multiple organ injury;pseudomonas;aeruginosa exotoxin A;necrosis-factor-alpha;gadolinium chloride;kupffer cells;liver-injury;in-vivo;b-1 hepatotoxicity;mice;apoptosis;endotoxin;posttreatment
Project: Immunopharmacology and Immunotoxicology
期刊/報告no:: Immunopharmacology and Immunotoxicology, Volume 31, Issue 1, Page(s) 75-82.
Pseudomonas aeruginosa Exotoxin A (PEA) induces hepatotoxicity in experimental animals. Lipopolysaccharide (LPS) interacts synergistically with xenotoxics to induce severe organ injury. We examined the combination of non-injurious doses of LPS and sub-hepatotoxic PEA in the induction of multiple organ injury (MOI). Rats treated with 20 or 40 g/kg LPS plus 10 g/kg PEA developed severe liver, kidney, and lung injury; elevation of TNF-, IFN-, and IL-2; and high mortality. Depletion of Kupffer cells or T-cells by pretreatment with Gadolinium Chloride or FK506, respectively, attenuated MOI. Thus LPS + PEA acted synergistically on Kupffer and T-cells to induce proinflammatory cytokines contributing to MOI.
ISSN: 0892-3973
DOI: 10.1080/08923970802357724
Appears in Collections:獸醫學系所

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