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標題: Serum Alpha-fetoprotein in Rabbits Experimentally Infected with Rabbit Haemorrhagic Disease Virus
作者: Chen, S.Y.
Shien, J.H.
Ooi, H.K.
關鍵字: Alpha-fetoprotein;rabbit haemorrhagic disease;serum enzymes;hepatocellular-carcinoma;hepatitis;purification;field
Project: Acta Veterinaria Brno
期刊/報告no:: Acta Veterinaria Brno, Volume 78, Issue 3, Page(s) 477-481.
To investigate the change in serum alpha-fetoprotein (AFP) and its correlation with liver enzymes in hepatitis caused by rabbit haemorrhagic disease virus (RHDV), 15-week-old rabbits were experimentally infected with a Taiwan field isolate of the virus. After RHDV inoculation, it was observed that serum AFP increased significantly (p = 0.0082) together with significant elevation in serum aspartate amino transferase (AST), alanine amino transferase (ALT), gamma-glutamyl transferase (gamma-GT) and alkaline phosphatase (ALP). Rabbits that died tended to have high AFP values prior to death, the mean value being 4.22 +/- 1.61 ng/ml (n = 6). By correlation analysis, AFP significantly correlated more strongly to ALP than gamma-GT, but non-significantly with AST and ALT. This is the first report of serum AFP elevation being associated with RHDV infection. Thus, measurement of serum AFP might be a useful complementary index for RHDV infectivity and prognosis.
ISSN: 0001-7213
DOI: 10.2754/avb200978030477
Appears in Collections:獸醫學系所

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