Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32926
標題: Hyperlipidemia in Rabbit Hemorrhagic Disease
作者: Chen, S.Y.
黃鴻堅
Shien, J.H.
Ooi, H.K.
關鍵字: cholesterol;rabbit hemorrhagic disease;triglyceride;viral-hepatitis;calicivirus;virus
Project: Experimental Animals
期刊/報告no:: Experimental Animals, Volume 57, Issue 5, Page(s) 479-483.
摘要: 
Clinically healthy rabbits were inoculated with rabbit hemorrhagic disease virus (RHDV) and the kinetics of their serum lipid parameters and liver enzymes were monitored. After RHDV inoculation, hyperlipidemia was observed (P-triglyceride<0.0001, P-cholesterol=0.0003) along with significant increases in serum aspartate aminotransferase, alanine aminotransferase and gamma-glutamyltransferase (P<0.0001). An exponential increase in serum triglyceride was also seen. Thus, the presence of hyperlipidemia (from 30 h post-inoculation) in the infected rabbits points to impairment in lipid metabolism. This is the first demonstration that RHDV infection leads to hyperlipidemia, probably due to the disorder of liver enzymes associated with lipid metabolism.
URI: http://hdl.handle.net/11455/32926
ISSN: 1341-1357
DOI: 10.1538/expanim.57.479
Appears in Collections:獸醫學系所

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