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標題: Abnormal distribution of anionic sites in the glomerular basement membrane in glomerulonephritis of dogs infected with Dirofilaria immitis
作者: Kamiie, J.
Shirota, K.
Yamaki, M.
Kitagawa, H.
Wasaki, M.
Ooi, H.K.
關鍵字: anionic site;canine dirofilariasis;glomerulonephritis
Project: Journal of Veterinary Medical Science
期刊/報告no:: Journal of Veterinary Medical Science, Volume 62, Issue 11, Page(s) 1193-1195.
Ultrastructural alteration of anionic sites (ASs) in the glomerular basement membrane (GBM) was studied in glomerulonephritis characterized by linear capillary Ige deposition in four dogs infected with Dirofilaria immitis and two normal control dogs using polyethyleneimine. ASs were identified as small dense particles distributed regularly in the lamina rara externa (LRE), but there were no ASs in the lamina densa (LD) of the GEM of the control dogs. In the glomeruli of the infected dogs, ASs were distributed regularly or irregularly in the thickened LD. ASs were in addition localized over the characteristic continuous bands of subendothelial dense deposits. The number of ASs of the LRE increased in all four infected cases as compared to the controls (p<0.01).
ISSN: 0916-7250
DOI: 10.1292/jvms.62.1193
Appears in Collections:獸醫學系所

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