Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32974
DC FieldValueLanguage
dc.contributor.authorChen, G.D.en_US
dc.contributor.author董光中zh_TW
dc.contributor.authorPeng, H.Y.en_US
dc.contributor.authorTung, K.C.en_US
dc.contributor.authorCheng, C.L.en_US
dc.contributor.authorChen, Y.J.en_US
dc.contributor.authorLiao, J.M.en_US
dc.contributor.authorHo, Y.C.en_US
dc.contributor.authorPan, S.F.en_US
dc.contributor.authorChen, M.J.en_US
dc.contributor.authorLin, T.B.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-06T07:44:32Z-
dc.date.available2014-06-06T07:44:32Z-
dc.identifier.issn1931-857Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/32974-
dc.description.abstractThis study was conducted to investigate whether dorsolateral pontine tegmentum stimulation modulates spinal reflex potentiation (SRP) and whether serotonergic neurotransmission is involved in such a modulation. Reflex activities of the external urethra sphincter (EUS) electromyogram in response to a test stimulation (TS; 1/30 Hz) or repetitive stimulation (RS; 1 Hz) on the pelvic afferent nerve in 35 anesthetized rats were recorded with/without synchronized train pontine stimulation (PS; 300 Hz, 30 ms) and/or intrathecal administrations of 10 mu l of 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo (F) quinoxaline (NBQX; 100 mu M), D-2-amino-5-phosphonovalerate (APV; 100 mu M), N-[2-[4-( 2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl) cyclohexanecarboxamide trihydrochloride (WAY 100635; 100 mu M), and 8-hydroxy-2-( di-n-propylamino)-tetralin (8-OH-DPAT; 100 mu M). The TS evoked a single action potential (1.00 +/- 0.00 spikes/stimulation), while the RS produced a long-lasting SRP (16.12 +/- 1.59 spikes/stimulation) that was abolished by APV (1.57 +/- 0.29 spikes/stimulation) and was attenuated by NBQX (7.42 +/- 0.57 spikes/stimulation). Synchronized train PS with RS (PS+RS) produced facilitation in RS-induced SRP (25.17 +/- 2.21 spikes/stimulation). Intrathecal WAY 100635 abolished the facilitation in SRP as a result of the synchronized PS (14.66 +/- 1.58 spikes/stimulation). On the other hand, intrathecal 8-OH-DPAT elicited facilitation in the RS-induced SRP (25.16 +/- 1.05 spikes/ stimulation) without synchronized PS. Our findings suggest that dorsolateral pontine tegmentum may modulate N-methyl-D-aspartic acid-dependent SRP via descending serotonergic neurotransmission. This descending modulation may have physiological/pharmacological relevance in the neural controls of urethral closure.en_US
dc.language.isoen_USzh_TW
dc.relationAmerican Journal of Physiology-Renal Physiologyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology-Renal Physiology, Volume 293, Issue 4, Page(s) F1115-F1122.en_US
dc.relation.urihttp://dx.doi.org/10.1152/ajprenal.00135.2007en_US
dc.subjectlong term potentiationen_US
dc.subjectSRPen_US
dc.subjectpontine tegmentumen_US
dc.subjectserotoninen_US
dc.subjectWAY 100635en_US
dc.subject8-OH-DPATen_US
dc.subjectlong-term potentiationen_US
dc.subjectexternal urethral sphincteren_US
dc.subjectloweren_US
dc.subjecturinary-tracten_US
dc.subjectmicturition-reflexen_US
dc.subjectanesthetized ratsen_US
dc.subjectsynaptic-transmissionen_US
dc.subjectbinding-sitesen_US
dc.subjectnerve injuryen_US
dc.subjectdorsal-hornen_US
dc.subjectalpha-amino-3-hydroxy-5-methylisoxazole-4-propionic aciden_US
dc.titleDescending facilitation of spinal NMDA-dependent reflex potentiation from pontine tegmentum in ratsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1152/ajprenal.00135.2007zh_TW
item.fulltextno fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
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