Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32976
DC FieldValueLanguage
dc.contributor.authorPeng, H.Y.en_US
dc.contributor.author董光中zh_TW
dc.contributor.authorChen, G.D.en_US
dc.contributor.authorLai, C.H.en_US
dc.contributor.authorTung, K.C.en_US
dc.contributor.authorChang, J.L.en_US
dc.contributor.authorLin, T.B.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T07:44:32Z-
dc.date.available2014-06-06T07:44:32Z-
dc.identifier.issn1931-857Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/32976-
dc.description.abstractPeng H, Chen G, Lai C, Tung K, Chang J, Lin T. Endogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2B. Am J Physiol Renal Physiol 298: F109-F117, 2010. First published October 28, 2009; doi:10.1152/ajprenal.00287.2009.-Recently, the role of EphB receptor (EphBR) tyrosine kinase and their ephrinB ligands in spinal pain-related neural plasticity has been identified. To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-D-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation. We found MO instillation produced colon-urethra reflex sensitization along with an upregulation of endogenous ephrinB2 expression as well as phosphorylation of EphB1/2, Src-family kinase, and NR2B tyrosine residues. Intrathecal immunoglobulin fusion protein of EphB1 and EphB2 as well as PP2 reversed the reflex sensitization and NR2B phosphorylation caused by MO. All these results suggest that EphBR-ephrinB interactions, which provoke Src-family kinase-dependent NMDAR NR2B phosphorylation at the lumbosacral spinal cord level, are involved in cross-organ sensitization, contributing to the development of viscero-visceral referred pain between the bowel and the urethra.en_US
dc.language.isoen_USzh_TW
dc.relationAmerican Journal of Physiology-Renal Physiologyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology-Renal Physiology, Volume 298, Issue 1, Page(s) F109-F117.en_US
dc.relation.urihttp://dx.doi.org/10.1152/ajprenal.00287.2009en_US
dc.subjectpelvic pain syndromeen_US
dc.subjecturethraen_US
dc.subjectirritable bowel syndromeen_US
dc.subjectcolonen_US
dc.subjectNMDAen_US
dc.subjectspinal reflex potentiationen_US
dc.subjectnmda receptor regulationen_US
dc.subjectd-aspartateen_US
dc.subjectreceptoren_US
dc.subjectinflammatory hyperalgesiaen_US
dc.subjectsynaptic plasticityen_US
dc.subjectneuropathicen_US
dc.subjectpainen_US
dc.subjectephb receptorsen_US
dc.subjectsubuniten_US
dc.subjectratsen_US
dc.subjectmaintenanceen_US
dc.titleEndogenous ephrinB2 mediates colon-urethra cross-organ sensitization via Src kinase-dependent tyrosine phosphorylation of NR2Ben_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1152/ajprenal.00287.2009zh_TW
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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