Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/32977
DC FieldValueLanguage
dc.contributor.authorLiao, J.M.en_US
dc.contributor.author董光中zh_TW
dc.contributor.authorYang, C.H.en_US
dc.contributor.authorCheng, C.L.en_US
dc.contributor.authorPan, S.F.en_US
dc.contributor.authorChen, M.J.en_US
dc.contributor.authorHuang, P.C.en_US
dc.contributor.authorChen, G.D.en_US
dc.contributor.authorTung, K.C.en_US
dc.contributor.authorPeng, H.Y.en_US
dc.contributor.authorLin, T.B.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-06T07:44:33Z-
dc.date.available2014-06-06T07:44:33Z-
dc.identifier.issn1931-857Xzh_TW
dc.identifier.urihttp://hdl.handle.net/11455/32977-
dc.description.abstractThe purposes of this study were to investigate whether the pelvic nerve-to-external urethra sphincter (EUS) reflex potentiation can be induced under physiological conditions and to determine whether glutamatergic neurotransmission is involved in the reflex potentiation. Stimulation-evoked reflex activities, during rhythmic bladder contractions caused by a continuous saline infusion, in 21 anesthetized rats were recorded with/without the intrathecal administration of 10 mu l of CNQX ( a glutamatergic AMPA receptor antagonist; 100 mu M) and APV( a glutamatergic NMDA receptor antagonist; 100 mu M). Reflex activities became potentiated following the increment of intravesical pressure (IVP) during the storage phase (2.39 +/- 0.28 spikes/mmHg, n = 21) and the ascending period of the voiding phase (1.46 +/- 0.35 spikes/mmHg, n = 21) and decreased following the decrement of IVP during the descending period of the voiding phase (1.50 +/- 0.33 spikes/mmHg, n = 21). Although it is characterized by a low IVP, a postvoiding reflex potentiation in stimulation-evoked activities was elicited at the critical period after a voiding contraction had just finished (23.95 +/- 8.96 spikes/mmHg, n = 21). The slope of the regression line of evoked activities vs. the IVP during the storage phase was significantly (P < 0.01) higher than that of the ascending and descending periods of the voiding phase, but there was no statistical difference between the ascending and the descending periods (P > 0.05). In addition, the slope of the regression line of posttetanic reflex potentiation was significantly higher than that of the storage phase (P < 0.01). All the slopes of the regression lines decreased after intrathecal CNQX administration ( from 3.15 +/- 0.44, 2.10 +/- 0.57, 2.13 +/- 0.53, and 21.30 +/- 3.41 to 0.83 +/- 0.31, 0.74 +/- 0.12, 0.76 +/- 0.12, and 4.31 +/- 3.71 spikes/mmHg in storage, ascending and descending period of the voiding phase, and postvoiding potentiation, respectively; all P < 0.01, n = 10). The slopes of the regression lines became almost horizontal after intrathecal APV administration ( from 3.15 +/- 0.44, 2.10 +/- 0.57, 2.13 +/- 0.53, and 21.30 +/- 3.41 to 0.16 +/- 0.12, 0.21 +/- 0.07, 0.18 +/- 0.05, and 0.23 +/- 0.76 spikes/mmHg in storage, ascending and descending period of voiding phase, and postvoiding potentiation, respectively; all P < 0.01, n = 10). Our results suggest that a potentiation in the pelvic nerve-to-EUS reflex can be induced under physiological conditions and the glutamatergic mechanism appears to be involved in this reflex potentiation.en_US
dc.language.isoen_USzh_TW
dc.relationAmerican Journal of Physiology-Renal Physiologyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology-Renal Physiology, Volume 293, Issue 3, Page(s) F790-F800.en_US
dc.relation.urihttp://dx.doi.org/10.1152/ajprenal.00296.2006en_US
dc.subjectpostvoiding potentiationen_US
dc.subjectposttetanic potentiationen_US
dc.subjectglutamateen_US
dc.subjectlong-term potentiationen_US
dc.subjectlower urinary-tracten_US
dc.subjectmicturition-reflexen_US
dc.subjectreceptor antagonistsen_US
dc.subjectsynaptic-transmissionen_US
dc.subjectdorsal-hornen_US
dc.subjectalpha-amino-3-hydroxy-5-methylisoxazole-4-propionic aciden_US
dc.subjectlastingen_US
dc.subjectpotentiationen_US
dc.subjectbladder contractionen_US
dc.subjectcord-injuryen_US
dc.titleSpinal glutamatergic NMDA-dependent cyclic pelvic nerve-to-external urethra sphincter reflex potentiation in anesthetized ratsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1152/ajprenal.00296.2006zh_TW
item.languageiso639-1en_US-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:獸醫學系所
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