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標題: Preliminary report of associated factors in wound infection after major head and neck neoplasm operations - does the duration of prophylactic antibiotic matter?
作者: Liu, S.A.
Tung, K.C.
Shiao, J.Y.
Chiu, Y.T.
關鍵字: head and neck neoplasms;wound infection;prophylactic antibiotics;otorhinolaryngological surgical procedures;contaminated head;cancer surgery;risk-factors;complications;clindamycin;prevention;cefazolin;taiwan
Project: Journal of Laryngology and Otology
期刊/報告no:: Journal of Laryngology and Otology, Volume 122, Issue 4, Page(s) 403-408.
The aim of this study was to investigate whether an extended course of prophylactic antibiotic could reduce the wound infection rate in a subtropical country. Fifty-three consecutive cases scheduled to receive major head and neck operations were randomised into one-day or three-day prophylactic antibiotic groups. Thirteen cases (24.5 per cent) developed wound infections after operations. The duration of prophylactic antibiotic was not related to the surgical wound infection. However, pre-operative haemoglobulin less than 10.5 g/dl (odds ratio: 7.24, 95 per cent confidence interval: 1.28-41.0) and reconstruction with a free flap or pectoris major myocutaneous flap during the operation (odds ratio: 11.04, 95 per cent confidence interval: 1.17-104.7) were associated factors significantly influencing post-operative wound infection. Therefore, one day of prophylactic antibiotic was effective in major head and neck procedures but should not be substituted for proper aseptic and meticulous surgical techniques.
ISSN: 0022-2151
DOI: 10.1017/s0022215107007529
Appears in Collections:獸醫學系所

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