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標題: Alteration of extracellular collagen matrix in the myocardium of canines infected with Dirofilaria immitis
作者: Wang, J.S.
Tung, K.C.
Huang, C.C.
Lai, C.H.
關鍵字: Dirofilaria immitis;extracellular matrix;collagen;hypertrophic cardiomyopathy;cardiac interstitium;fibrillar collagen;heartworm disease;connective-tissue;network;fibroblasts;degradation
Project: Veterinary Parasitology
期刊/報告no:: Veterinary Parasitology, Volume 131, Issue 3-4, Page(s) 261-265.
The heart consists of cardiocytes and the interstitial extracellular matrix (ECM), which is made up mainly of collagens. The ECM has been suggested to be important in maintaining the structure and function of the heart. This investigation attempted to elucidate the changes in the ECM collagens in the hearts of canines with dirofilariasis. The ECM collagen fibrils of the heart are grouped into endomysial struts, epimysial weaves, and perimysail coils. In the present study, we used the modified silver impregnation technique to stain paraffin-embedded sections to demonstrate three types of ECK The results revealed that the ECM content of the heart was significantly reduced in heartworm-infected dogs, and became fragmented and dissociated. In addition, the amounts of collagen in the septum (Sep), RVs and LVs in canines with dirofilariasis (Sep = 11.55 +/- 0.65, RV = 12.07 +/- 0.59, LV = 11.72 +/- 0.62 mu g/mg, n = 24) were significantly lower (p < 0.01) than that in the normal canines (Sep = 15.09 +/- 0.72, RV = 15.16 +/- 0.83, LV = 14.91 +/- 0.89 mu g/mg, n = 8). These results indicated that heartworm infection induced the remodeling of the extracellular matrix, thus markedly altering the architecture and function of the heart. (c) 2005 Elsevier B.V. All rights reserved.
ISSN: 0304-4017
DOI: 10.1016/j.vetpar.2005.04.041
Appears in Collections:獸醫學系所

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