Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33017
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dc.contributor.authorLin, W.Y.en_US
dc.contributor.author鍾楊聰zh_TW
dc.contributor.authorChi, C.W.en_US
dc.contributor.authorHo, Y.J.en_US
dc.contributor.authorWu, I.C.en_US
dc.contributor.authorChung, Y.T.en_US
dc.contributor.authorChen, S.D.en_US
dc.contributor.authorChou, F.I.en_US
dc.contributor.authorKai, J.J.en_US
dc.contributor.authorLui, W.Y.en_US
dc.contributor.authorChen, T.J.en_US
dc.contributor.authorLin, Y.C.en_US
dc.date2002zh_TW
dc.date.accessioned2014-06-06T07:44:42Z-
dc.date.available2014-06-06T07:44:42Z-
dc.identifier.issn0250-7005zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/33017-
dc.description.abstractBackground: Boron neutron capture therapy (BNCT) is a form of radiation therapy and has been proposed for the treatment of some malignancies with encouraging results. However, none of them has ever been applied to liver malignancy. The purpose of this study was to evaluate the potential of boron-lipiodol (B-lipiodol) for the treatment of VX2 liver tumor via BNCT Materials and Methods: Twelve New Zealand rabbits were randomly separated into two groups: lipiodol and boron-lipiodol groups. The rabbits were anesthetized, a midline incision was made and the left lobe of the liver was injected with 0.1 ml of VX2 tumor cells. After the tumor reached 2-3 cm in diameter, the rabbits were anesthetized and 0.5 ml of boron-lipiodol was injected into the hepatic artery via an angiocatheter. Liver function tests and renal function tests were performed before, at 12 hours, 24 hours, 48 hours and 7 days after injection of drugs in both groups. The concentration of boron in various tissues was determined on the 7th day after injection. Results: Liver function was abnormal at 12 hours after injection, and then gradually returned to normal at 7 days, indicative of acute temporary hepatic damage. As for the renal function, no significant change was noted in either group. The boron level was 49.7 ppm in tumor and 631 ppm in the healthy liver 7 days after injection of B-lipiodol. The ratio of boron concentrations between the tumor and the normal liver tissue was 7.87 As for blood and other organs including spleen, heart and kidney, the concentration of boron was low. In the lipiodol group, the boron concentrations in tumor and various organs were low. Conclusion: The high concentration of boron after intra-arterial injection of B-lipiodol can be used for neutron capture therapy. B-lipiodol has potential for the treatment of liver malignancy.en_US
dc.language.isoen_USzh_TW
dc.relationAnticancer Researchen_US
dc.relation.ispartofseriesAnticancer Research, Volume 22, Issue 6C, Page(s) 3989-3992.en_US
dc.subjectboron-lipiodolen_US
dc.subjectliver tumorsen_US
dc.subjectneutron-capture therapyen_US
dc.subjecthepatocellular-carcinomaen_US
dc.subjectintraarterialen_US
dc.subjectinjectionen_US
dc.subjectcomputerized-tomographyen_US
dc.subjectintratumoral injectionen_US
dc.subjectp-boronophenylalanineen_US
dc.subjectimage-enhancementen_US
dc.subjectcontrast-mediumen_US
dc.subjectiodized oilen_US
dc.subjectcanceren_US
dc.titleBoron-lipiodol: A potential new drug for the treatment of liver tumorsen_US
dc.typeJournal Articlezh_TW
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
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