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標題: Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice
作者: Liu, Hsien Yueh
Chung, Chih-Yao
Yang, Wen-Chin
Liang, Chih-Lung
Wang, Chi-Young
Chang, Chih-Yu
Chang, Cicero Lee-Tian
關鍵字: diabetes mellitus;exendin-4;Listeria monocytogenes;macrophage;mice
Project: J. Vet. Sci., Volume 13, Issue 3, Page(s) 245-252.
The incidence of diabetes mellitus is increasing among
companion animals. This disease has similar characteristics in
both humans and animals. Diabetes is frequently identified as
an independent risk factor for infections associated with
increased mortality. In the present study, homozygous
diabetic (db/db) mice were infected with Listeria (L.)
monocytogenes and then treated with the anti-diabetic drug
exendin-4, a glucagon-like peptide 1 analogue. In aged db/db
mice, decreased CD11b+ macrophage populations with higher
lipid content and lower phagocytic activity were observed.
Exendin-4 lowered high lipid levels and enhanced
phagocytosis in macrophages from db/db mice infected with
L. monocytogenes. Exendin-4 also ameliorated obesity and
hyperglycemia, and improved ex vivo bacteria clearance by
macrophages in the animals. Liver histology examined during
L. monocytogenes infection indicated that abscess formation
was much milder in exendin-4-treated db/db mice than in the
control animals. Moreover, mechanistic studies demonstrated
that expression of ATP binding cassette transporter 1, a sterol
transporter, was higher in macrophages isolated from the
exendin-4-treated db/db mice. Overall, our results suggest
that exendin-4 decreases the risk of infection in diabetic
animals by modifying the interaction between intracellular
lipids and phagocytic macrophages.
ISSN: 1976-555X
DOI: 10.4142/jvs.2012.13.3.245
Appears in Collections:獸醫學系所

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