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標題: Regulation of virus-induced inflammatory response by b-carotene in RAW264.7 cells
作者: Lin, Hui-Wen
Chang, Tien-Jye
Yang, Deng-Jye
Chen, Yi-Chen
Wang, Meilin
Chang, Yuan-Yen
關鍵字: beta-Carotene;Pseudorabies virus (PRV);Anti-inflammatory;Macrophage
Project: Food Chemistry, Volume 134, Page(s) 2169–2175.
Carotenoids are effective antioxidants, which can quench singlet oxygen, suppress lipid peroxidation, and
prevent oxidative damage. Both Pseudorabies virus (PRV) and human Herpes simplex virus (HSV) are
DNA viruses, and their pathogenesis and immunobiology are similar. However, PRV does not infect
humans. Therefore, PRV was used to infect murine macrophages (RAW264.7 cells), to mimic
HSV-induced inflammation. Meanwhile, the influence of b-carotene on PRV-induced inflammation was
also investigated. Results indicated that b-carotene inhibited (p < 0.05) NO, IL-1b, IL-6, and MCP-1 production
in PRV-infected RAW264.7 cells. b-Carotene also suppressed (p < 0.05) NF-jB (p50 and p65),
phosphorylation of extracellular-signal-related kinase (ERK), p38, and c-Jun N-terminal kinase (JNK)
expression. It could be concluded that the anti-inflammatory effect of b-carotene is mainly through a suppression
of cytokine expression in PRV-induced inflammation, which results from NF-jB inactivation. b-
Carotene can be considered a potential anti-inflammatory agent for DNA-virus infection.
ISSN: 0308-8146
DOI: 10.1016/j.foodchem.2012.04.024
Appears in Collections:獸醫學系所

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