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標題: Hepatoprotective Effect of Shidagonglao on Acute Liver Injury Induced by Carbon Tetrachloride
作者: Chao, J.
Lee, M.S.
Amagaya, S.
Liao, J.W.
Wu, J.B.
Ho, L.K.
Peng, W.H.
關鍵字: Shidagonglao;Hepatoprotective Effect;Carbon Tetrachloride;Anti-Oxidative Effect;Anti-Inflammatory Activity;tumor-necrosis-factor;protective mechanism;alternative medicine;lipid-peroxidation;nitric-oxide;rats;hepatotoxicity;glutathione;damage;complementary
Project: American Journal of Chinese Medicine
期刊/報告no:: American Journal of Chinese Medicine, Volume 37, Issue 6, Page(s) 1085-1097.
This study investigates the hepatoprotective activity of ethanol extract from Shidagonglao roots (SDGL(EtOH)). The hepatoprotective effect of SDGL(EtOH) (20, 100 and 500 mg/kg) was analyzed on carbon tetrachloride (CCl(4))-induced acute liver injury. Rats pretreated orally with SDGL(EtOH) (100 and 500 mg/kg) and silymarin (200 mg/kg) for 3 consecutive days prior to the administration of a single dose of 50% CCl(4) (0.10ml/100 g of bw, ip) significantly prevented the increases in the activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in CCl(4)-treated rats. Histological analysis also showed that SDGL(EtOH) (100 and 500 mg/kg) and silymarin reduced the incidence of liver lesions including vacuole formation, neutrophil infiltration and necrosis of hepatocytes induced by CCl(4) in rats. Moreover, the SDGL(EtOH) (100 and 500 mg/kg) increased the activities of anti-oxidative enzymes, superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GRd) and decreased malondialdehyde (MDA) level in liver, as compared to those in the CCl(4)-treated group. Furthermore, SDGL(EtOH) (100 and 500 mg/kg) and silymarin attenuated the increased levels of tumor necrosis factor-alpha (TNF-alpha) in serum and nitric oxide (NO) in liver as compared to the CCl(4)-treated group. The hepatoprotective mechanisms of SDGL(EtOH) are likely related to inhibition of TNF-alpha, MDA and NO productions via increasing the activities of antioxidant enzymes (SOD, GPx and GRd). These experimental results suggest that SDGL(EtOH) can attenuate CCl(4)-induced acute liver injury in rats.
ISSN: 0192-415X
DOI: 10.1142/s0192415x0900751x
Appears in Collections:獸醫病理生物學所

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