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標題: Effects of sugar cane extract on pseudorabies virus challenge of pigs
作者: Lo, D.Y.
Chien, M.S.
Yeh, K.S.
Koge, K.
Lin, C.C.
Hsuan, S.L.
Lee, W.C.
關鍵字: immunomodulation;interferon-gamma;leukocyte function;pseudorabies;sugar cane extract;nk cells;infection;chickens;immunity;sce;kokuto;model
Project: Journal of Veterinary Medical Science
期刊/報告no:: Journal of Veterinary Medical Science, Volume 68, Issue 3, Page(s) 219-225.
This experiment aimed to evaluate the efficacy of sugar cane extract (SCE) on the modulation of porcine immunity against pseudorabies virus (PrV) infection. Twelve-week-old experimental pigs were fed with SCE (500 mg/kg of body weight per day) for 3 days and challenged with PrV (2 x 10(5) TCID50) on the second day. Pigs that were only challenged with PrV and without SCE-treatment served as controls. The leukocyte functional assays were performed on the 7th and 14th day post-PrV challenge. Our results showed a significant enhancement (P < 0.05) of natural killer cytotoxicity, lymphocyte proliferation, phagocytic function of monocytes, and interferon-gamma (IFN-gamma) production of CD4(+) and gamma delta T cells in the SCE-treated pigs compared with the controls. In addition, SCE administration reduced the severity of clinical signs and brain lesion in the course of disease in PrV-challenged pigs. SCE-treated pigs showed a 12% growth enhancement compared with untreated controls. SCE administration had an immunostimulating effect on porcine immunity that may subsequently enhance protective activities against PrV infection which may be extensively applied in field for the prevention of infections.
ISSN: 0916-7250
DOI: 10.1292/jvms.68.219
Appears in Collections:獸醫病理生物學所

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