Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33117
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dc.contributor.authorLee, S.D.en_US
dc.contributor.author陳德勛zh_TW
dc.contributor.authorChen, L.M.en_US
dc.contributor.authorKuo, W.W.en_US
dc.contributor.authorShu, W.T.en_US
dc.contributor.authorKuo, W.H.en_US
dc.contributor.authorHuang, E.J.en_US
dc.contributor.authorTsai, C.C.en_US
dc.contributor.authorLi, P.C.en_US
dc.contributor.authorLiu, J.Y.en_US
dc.contributor.authorChen, T.H.en_US
dc.contributor.authorHuang, C.Y.en_US
dc.date2006zh_TW
dc.date.accessioned2014-06-06T07:44:56Z-
dc.date.available2014-06-06T07:44:56Z-
dc.identifier.issn0009-8981zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/33117-
dc.description.abstractBackground: Insulin-like growth factor (IGF)-I plays an important role for maintaining cardiac functions. We clarified the unknown role of IGF-axis in rheumatic heart disease (RHD). Method: Interleukin (IL)-10, growth hormone (GH), IGF, IGF binding protein (IGFBP)-3 and matrix metalloproteinase (MMP) were measured by ELISA and zymography in 30 age range-matched normal subjects (control), 36 patients with acute phase of rheumatoid arthritis (RA) with positive rheumatoid factor (RF) and C-reactive protein (CRP), and in 43 patients with RHD with negative RF and CRP. Result: Compared with normal subjects, increased IL-10 level and decreased GH were found in RA group whereas unchanged IL-10 and decreased GH were found in RHD group. Compared with age range-matched normal subjects, decreased IGFBP-3, MMP-9 levels, unchanged IGF-I were found in RA group whereas decreased IGF-I levels, unchanged IGFBP3 and increased MMP-9 at age > 30 years were found in RHD group. IGF-II was not changed in RA and RHD groups. Conclusion: These findings may imply that during inflammatory phase, the levels of anti-inflammation was high and total lGF-I and IGF bioavailability were maintained in patients with RA. Our findings in RHD may speculate that the long-term reduction of GH and lGF-I as well as the compensating effects of upregulated MMP-9 activity may be partially involved in the long-term pathogenesis from RHD to heart failure. Decreased GH, decreased IGF-I and increased MMP-9 activities may be possible diagnostic markers in RHD for developing heart failure. (c) 2005 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationClinica Chimica Actaen_US
dc.relation.ispartofseriesClinica Chimica Acta, Volume 367, Issue 1-2, Page(s) 62-68.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.cca.2005.11.015en_US
dc.subjectendocrine systemen_US
dc.subjectGH-IGF-axisen_US
dc.subjectMMPsen_US
dc.subjectrheumatic heart diseaseen_US
dc.subjectfactor-ien_US
dc.subjectigf-ien_US
dc.subjectinterleukin-10en_US
dc.subjecthormoneen_US
dc.subjectfailureen_US
dc.subjectcytokinesen_US
dc.subjectfeveren_US
dc.subjectassociationen_US
dc.subjectexpressionen_US
dc.subjecttherapyen_US
dc.titleSerum insulin-like growth factor-axis and matrix metalloproteinases in patients with rheumatic arthritis or rheumatic heart diseaseen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.cca.2005.11.015zh_TW
item.grantfulltextnone-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
Appears in Collections:獸醫病理生物學所
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