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標題: Different bacteria species lipopolysaccharide co-exposure with Pseudomonas exotoxin A on multiple organ injury induction
作者: Chuang, H.L.
Chiu, C.C.
Chen, T.H.
Chen, H.H.C.
Chu, Y.Y.
Huang, Y.T.
關鍵字: necrosis-factor-alpha;salmonella-typhimurium endotoxemia;a-induced;hepatotoxicity;lethal escherichia-coli;aeruginosa exotoxin;liver-injury;mice;rats;cells;modulation
Project: Immunopharmacology and Immunotoxicology
期刊/報告no:: Immunopharmacology and Immunotoxicology, Volume 31, Issue 4, Page(s) 616-624.
The present study investigated the effect of different bacterial species lipopolysaccharide plus Pseudomonas exotoxin A (LPS/PEA) on the induction of multiple organ injury (MOI). Rats were injected with various LPS from Salmonella (SAE, SAT), E. coli (EB4, EB5), or P. aeruginosa (PAL) and PEA showed a greater mortality in the SAE/PEA and SAT/PEA groups. Histological alterations, serum enzymes, and cytokines changes were severer in the SAE/PEA group than the EB4/PEA or PAL/PEA group. EB4/PEA and PAL/PEA failed to induce MOI, even at the LPS doses increased up to 2-4- and 4-8-fold, respectively. Rats co-treated with Salmonella lipid A/PEA developed severer MOI than the E. coli lipid A/PEA. The results indicated the critical roles of MOI induction, which were related to LPS derived from appropriate bacterial species.
ISSN: 0892-3973
DOI: 10.3109/08923970902926402
Appears in Collections:獸醫病理生物學所

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