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標題: Effect of Cordyceps Militaris Supplementation on Sperm Production, Sperm Motility and Hormones in Sprague-Dawley Rats
作者: Chang, Y.
Jeng, K.C.
Huang, K.F.
Lee, Y.C.
Hou, C.W.
Chen, K.H.
Cheng, F.Y.
Liao, J.W.
Chen, Y.S.
關鍵字: Cordyceps militaris;Sperm Production;Sperm Motility;Sex Hormones;sinensis mycelium;semen quality;dietary selenium;vitamin-e;in-vitro;mouse;cells;spermatogenesis;performance;mechanism
Project: American Journal of Chinese Medicine
期刊/報告no:: American Journal of Chinese Medicine, Volume 36, Issue 5, Page(s) 849-859.
Cordyceps species have been traditionally used its for the enhancement of sexual function. but its direct evidence is lacking. We investigated the spermatogenic effect of Cordyceps militaris (CM) as supplementation with CM mycelium to 7-week-old male Sprague-Dawley (SD) rats. Ninety rats (30 for each group) were selected to regular diet or diet Supplemented with CM mycelium (1% and 5%) For 6 weeks. Epididymal sperm were collected from 6 animals per group Lit each interval of observation. They were allowed to recover for one week. The quality and quantity of sperm were compared in these rats. The CM Supplementation resulted in an increase of serum cordycepin concentration (n = 6. each group) that correlated with treatment time and the cordycepin level was significantly higher (p < 0.05) in 5% group as compared to 1% group at the 5th and 6th week. Epididymal sperm count was enhanced significantly from the control. at the 5th week and peaked at the 6th week in both groups supplemented with CM (each time point, n = 6; p < 0.05) and maintained for 2 weeks after stopping the treatment. Increased serum testosterone and estradiol-17 (E2) concentrations were found in rats with the CM supplementation (p < 0.05), but not other hormones such as follicle Stimulating hormone (FSH), luteinizing hormone (LH) or prolactin. Importantly, percentages of motile sperm cells were also enhanced significantly (p < 0.05) paralleled the serum testosterone pattern from the supplement groups as compared to the control group. Taken together, these results indicate that supplementation with CM improves sperm quality and quantity in rats.
ISSN: 0192-415X
DOI: 10.1142/s0192415x08006296
Appears in Collections:獸醫病理生物學所

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