Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33155
DC FieldValueLanguage
dc.contributor.authorTsai, Y.T.en_US
dc.contributor.author廖俊旺zh_TW
dc.contributor.authorCheng, P.C.en_US
dc.contributor.authorLiao, J.W.en_US
dc.contributor.authorPan, T.M.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T07:45:01Z-
dc.date.available2014-06-06T07:45:01Z-
dc.identifier.issn1567-5769zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/33155-
dc.description.abstractThe role of lactic acid bacteria in gut mucosal immunity was investigated by comparing the enhanced effects in the Peyer's patches and spleen of BALB/c mice fed daily with Lactobacillus paracasei subsp. paracasei NTU 101 for 3 to 9 weeks. After feeding with Lactobacillus, the percentage of CD4(+) T cells in both Peyer's patches and the spleen was significantly increased: however, expression of CD 154 molecules, which play a pivotal role in cell-to-cell communication, on CD4(+) T cells and the percentage of B220(+) B cells increased only in Peyer's patches. Compared with systemic serum IgA, Peyer's patch-derived immunomodulation induced higher levels of intestinal IgA(+)-producing cells in the lamina propria. Our data also showed that feeding with Lactobacillus induced stronger CD4(+) T cell-dendritic cell interaction, enhanced CD4(+) T cell and B cell proliferation, and increased IL-1 beta, 1L-10, IL-12, IFN-gamma, and TNF-alpha mRNA expression in Peyer's patches, but not in the spleen. Here, we demonstrate that following Lactobacillus treatment, Peyer's patches exhibited a more distinct capacity to induce CD4(+) T cell-dendritic cell interactions, lymphocyte proliferation, and cytokine secretion than the spleen, and thereby promoted greater intestinal IgA production that could enhance immunosurveillance to prevent intestinal infections or other intestinal pathologies. (C) 2010 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationInternational Immunopharmacologyen_US
dc.relation.ispartofseriesInternational Immunopharmacology, Volume 10, Issue 7, Page(s) 791-798.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.intimp.2010.04.012en_US
dc.subjectPeyer's patchesen_US
dc.subjectMucosal immunityen_US
dc.subjectImmunomodulationen_US
dc.subjectProbioticsen_US
dc.subjecthuman dendritic cellsen_US
dc.subjectnaive b-cellsen_US
dc.subjectt-cellsen_US
dc.subjectlymph-nodesen_US
dc.subjectcd40 liganden_US
dc.subjectguten_US
dc.subjectspleenen_US
dc.subjectmilken_US
dc.subjectpersistenceen_US
dc.subjectexpressionen_US
dc.titleEffect of the administration of Lactobacillus paracasei subsp paracasei NTU 101 on Peyer's patch-mediated mucosal immunityen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.intimp.2010.04.012zh_TW
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.grantfulltextnone-
item.openairetypeJournal Article-
Appears in Collections:獸醫病理生物學所
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