Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33166
DC FieldValueLanguage
dc.contributor.authorLiao, J.W.en_US
dc.contributor.author廖俊旺zh_TW
dc.contributor.authorHong, L.Z.en_US
dc.contributor.authorWang, M.F.en_US
dc.contributor.authorTsai, S.C.en_US
dc.contributor.authorLin, Y.J.en_US
dc.contributor.authorChan, Y.C.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T07:45:03Z-
dc.date.available2014-06-06T07:45:03Z-
dc.identifier.issn0022-1147zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/33166-
dc.description.abstractNanotechnology, as a new enabling technology, has the potential to revolutionize food systems. However, much attention has been focused on nanoparticle foods due to their potential physiological properties. This study was aimed to evaluate the mutagenic safety and fatty liver improvement of black soybean in senescence-accelerated mice (SAMP8). The mutagenic activity of black soybeans was investigated using the Ames test (Salmonella Typhimurium TA98, 100, 102, and 1535). Furthermore, senescence-accelerated prone-8 mice (SAMP8) have been reported to display spontaneous fatty liver. Male SAMP8 mice were divided into control and supplemented with 10% micronized or nanonized black soybeans diet and fed for 12 wk. The results revealed that the Ames test of micronized and nanonized black soybeans exhibited no mutagenicity. Administration of black soybeans to mice showed no effects on food intake and body and organ weights. The nanonized black soybean group had a lower degree of spontaneous fatty liver, alanine aminotransferase, and thiobarbituric acid-reactive substance concentrations, and had enhanced superoxide dismutase, catalase, and glutathione peroxidase activities of livers when compared with the SAMP8 control and micronized black soybean groups. The mice fed with black soybeans had significantly lower triglyceride concentrations than the SAMP8 control group. The results of this study suggest that nanonized black soybeans have no side effects and, moreover, may minimize liver lesions in SAMP8 mice.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Food Scienceen_US
dc.relation.ispartofseriesJournal of Food Science, Volume 75, Issue 5, Page(s) T82-T90.en_US
dc.relation.urihttp://dx.doi.org/10.1111/j.1750-3841.2010.01638.xen_US
dc.subjectfatty liveren_US
dc.subjectnanonized black soybeanen_US
dc.subjectsafetyen_US
dc.subjectsenescence-accelerateden_US
dc.subjectmiceen_US
dc.subjectdensity-lipoprotein oxidationen_US
dc.subjecthealthy adult miceen_US
dc.subjectnano-seen_US
dc.subjectin-vitroen_US
dc.subjectglutathione-peroxidaseen_US
dc.subjectsuperoxide-dismutaseen_US
dc.subjectsubchronic toxicityen_US
dc.subjectratsen_US
dc.subjectantioxidanten_US
dc.subjectgenisteinen_US
dc.titleMutagenic Safety and Fatty Liver Improvement of Nanonized Black Soybeans in Senescence-Accelerated Prone-8 Miceen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1111/j.1750-3841.2010.01638.xzh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairetypeJournal Article-
Appears in Collections:獸醫病理生物學所
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