Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/33180
DC FieldValueLanguage
dc.contributor.authorLin, Y.J.en_US
dc.contributor.author簡茂盛zh_TW
dc.contributor.authorDeng, M.C.en_US
dc.contributor.authorWu, S.H.en_US
dc.contributor.authorChen, Y.L.en_US
dc.contributor.authorCheng, H.C.en_US
dc.contributor.authorChang, C.Y.en_US
dc.contributor.authorLee, M.S.en_US
dc.contributor.authorChien, M.S.en_US
dc.contributor.authorHuang, C.C.en_US
dc.date2008zh_TW
dc.date.accessioned2014-06-06T07:45:05Z-
dc.date.available2014-06-06T07:45:05Z-
dc.identifier.issn0916-7250zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/33180-
dc.description.abstractSince outbreaks of highly pathogenic avian influenza (HPAI) in both human and poultry from 2003, it is critical to have effective vaccines. A cDNA fragment coding the entire hemagglutinin (HA) gene derived from an H5N1 strain (A/duck/China/E319-2/03) was cloned and expressed using the baculovirus system. Two weeks after receiving two doses of recombinant HA (rHA) vaccines, chickens develop high antibody response for hernagglutination inhibition (HI) at titer 7.2 log(2). Challenge studies revealed that vaccinated chickens with HI titers greater than 3 1092 Could have immunoprotection against the same HPAI H5N1 strain virus challenge through intranasal route. Additionally, HI titer of 5 log(2) determined whether the live viruses could not be detected from oropharyngeal, cloacal discharge or in tissues. This result suggests that the rHA expressed from baculovirus system could be a candidate for the development of a safe and efficient subunit vaccine for HPAI (H5N1).en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Veterinary Medical Scienceen_US
dc.relation.ispartofseriesJournal of Veterinary Medical Science, Volume 70, Issue 11, Page(s) 1147-1152.en_US
dc.relation.urihttp://dx.doi.org/10.1292/jvms.70.1147en_US
dc.subjectbaculovirus expression systemen_US
dc.subjectH5N1en_US
dc.subjecthemagglutination inhibitionen_US
dc.subjecthighlyen_US
dc.subjectpathogenic avian influenza (HPAI)en_US
dc.subjectsubunit vaccineen_US
dc.subjectavian influenza-virusesen_US
dc.subjectreverse geneticsen_US
dc.subjectanimals strategyen_US
dc.subjectdnaen_US
dc.subjectvaccineen_US
dc.subjectefficacyen_US
dc.subjectevolutionen_US
dc.subjectinfectionen_US
dc.subjectducksen_US
dc.subjectoutbreaken_US
dc.subjectsubtypesen_US
dc.titleBaculovirus-Derived Hemagglutinin Vaccine Protects Chickens from Lethal Homologous Virus H5N1 Challengeen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1292/jvms.70.1147zh_TW
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
Appears in Collections:獸醫病理生物學所
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