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標題: Alkyne-mediated domino hydroformylation/double cyclization: mechanistic insight and synthesis of (+/-)-tashiromine
作者: Chiou, Wen-Hua
Lin, Yi-Huei
Chen, Guei-Tang
Gao, Yu-Kai
Tseng, Yu-Che
Kao, Chien-Lun
Tsai, Jui-Chi
關鍵字: stereoselective hydroformylation;indolizidine alkaloids;aza-annulation;(+)-tashiromine;tashiromine;route;(+/-)-5-epitashiromine;strategies;reduction;chemistry
Project: Chemical Communications, Volume 47, Issue 12, Page(s) 3562-3564.
A novel domino reaction, alkyne-mediated domino hydroformylation/double cyclization, has been developed for rapid preparation of indolizidine type alkaloids. DFT calculations were applied for rationales of reactivity and selectivity. A concise synthesis of tashiromine as the application of the methodology is also reported.
ISSN: 1359-7345
DOI: 10.1039/c0cc05646d
Appears in Collections:化學系所

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