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|標題:||Solid phase microextraction with liquid chromatography-electrospray ionization-tandem mass spectrometry for analysis of amphetamine and methamphetamine in serum||作者:||Chou, C.C.
|關鍵字:||amphetamine and methamphetamine;serum;solid phase microextraction;LC-ESI-MS/MS;methylenedioxy derivatives;recreational drugs;biological-fluids;human;plasma;extraction;urine;quantitation;samples;fibers;trends||Project:||Analytica Chimica Acta||期刊/報告no：:||Analytica Chimica Acta, Volume 538, Issue 1-2, Page(s) 49-56.||摘要:||
This investigation evaluates solid phase microextraction (SPME) combined with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) to determine trace levels of amphetamine (AM) and methamphetamine (MA) in serum. Chromatography was performed on a C-18 reversed-phase column using a linear gradient of acetonitrile-water as a mobile phase. Using sample extraction by SPME at optimum conditions, analytes were desorbed with static desorption in SPME-HPLC desorption chamber for 1 min and then determined with LC-ESI-MS/MS. The detection limits for amphetamine and methamphetamine in serum were 0.3 μ g/L and 0.04 μ g/L, respectively. According to the analysis, the linearity range is from 0.5 μ g/L to 200 μ g/L with R.S.D. values below 8%. The feasibility of applying the methods to determine amphetamine and methamphetamine in real samples was examined by analyzing serum samples from methamphetamine abused suspects. © 2005 Elsevier B.V. All rights reserved.
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