Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34125
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dc.contributor.authorWay, T.D.en_US
dc.contributor.author李茂榮zh_TW
dc.contributor.authorLin, H.Y.en_US
dc.contributor.authorKuo, D.H.en_US
dc.contributor.authorTsai, S.J.en_US
dc.contributor.authorShieh, J.C.en_US
dc.contributor.authorWu, J.C.en_US
dc.contributor.authorLee, M.R.en_US
dc.contributor.authorLin, J.K.en_US
dc.date2009zh_TW
dc.date.accessioned2014-06-06T07:47:12Z-
dc.date.available2014-06-06T07:47:12Z-
dc.identifier.issn0021-8561zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34125-
dc.description.abstractIn the present study, we successively extracted the pu-erh raw tea with methanol (PR-1), chloroform (PR-2), ethyl acetate (PR-3), n-butanol (PR-4), and water (PR-5). Among these extracts, PR-3 extract contained ingredients with the most effective hypolipidemic potential and was further purified by column chromatography. Moreover, chronic administration of PR-3 provoked a significant reduction in levels of serum triglyceride and low-density lipoprotein (LDL) in rats. Our study demonstrated that fraction 5 from the PR-3 extract (PR-3-5s) showed a hypolipidemic effect in human hepatoma HepG2 cells. PR-3-5s decreased the expression of fatty acid synthase (FASN) and inhibited the activity of acetyl-coenzyme A carboxylase (ACC) by stimulating AMP-activated protein kinase (AMPK) through the LKB1 pathway. Moreover, PR-3-5s blocked the progression of the cell cycle at the G1 phase by inducing p53 expression and in turn upregulating p21 expression.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Agricultural and Food Chemistryen_US
dc.relation.ispartofseriesJournal of Agricultural and Food Chemistry, Volume 57, Issue 12, Page(s) 5257-5264.en_US
dc.relation.urihttp://dx.doi.org/10.1021/jf900730een_US
dc.subjectPu-erh teaen_US
dc.subjectAMPKen_US
dc.subjectFASNen_US
dc.subjectACCen_US
dc.subjecthyperlipidemiaen_US
dc.subjectfatty-acid synthaseen_US
dc.subjectgreen teaen_US
dc.subjectoxidative damageen_US
dc.subjectcanceren_US
dc.subjectratsen_US
dc.subjectpolyphenolsen_US
dc.subjectextractsen_US
dc.subjectpathwayen_US
dc.subjectenzymesen_US
dc.subjectoolongen_US
dc.titlePu-erh Tea Attenuates Hyperlipogenesis and Induces Hepatoma Cells Growth Arrest through Activating AMP-Activated Protein Kinase (AMPK) in Human HepG2 Cellsen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1021/jf900730ezh_TW
item.languageiso639-1en_US-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.openairetypeJournal Article-
item.fulltextno fulltext-
item.grantfulltextnone-
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