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|標題:||Analysis of aristolochic acid in nine sources of Xixin, a traditional Chinese medicine, by liquid chromatography/atmospheric pressure chemical ionization/tandem mass spectrometry||作者:||Jong, T.T.
|關鍵字:||Aristolochiaceae;aristolochic acid;Asarum species;LC/APCI/MS/MS;Xixin||Project:||Journal of Pharmaceutical and Biomedical Analysis||期刊/報告no：:||Journal of Pharmaceutical and Biomedical Analysis, Volume 33, Issue 4, Page(s) 831-837.||摘要:||
Aristolochic acid I (AA-I), which is a known nephrotoxin, is found in a commonly used Chinese medicine, Xixin, that originates from nine Asarum species (Aristolochiaceae) found in China. A method has been developed using reversed-phase liquid chromatography coupled with atmospheric pressure chemical ionization (APCI) tandem mass spectrometry under the positive ion detection mode [LC/(+)APCI/MS/MS] to determine the amount of AA-I in Xixin. The limit of detection of AA-I, estimated by monitoring with LC/MS/MS, was at the low mug/1 level. By applying this method to methanol extracts of nine Asarum species, the concentrations of AA-I were found to range from 3.3 ng/mg (Asarum sieboldii) to 3376.9 ng/mg (Asarum crispulatum). (C) 2003 Elsevier B.V. All rights reserved.
|Appears in Collections:||化學系所|
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