Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34172
DC FieldValueLanguage
dc.contributor.authorHo, H.P.en_US
dc.contributor.author李茂榮zh_TW
dc.contributor.authorLee, R.J.en_US
dc.contributor.authorChen, C.Y.en_US
dc.contributor.authorWang, S.R.en_US
dc.contributor.authorLi, Z.G.en_US
dc.contributor.authorLee, M.R.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-06T07:47:18Z-
dc.date.available2014-06-06T07:47:18Z-
dc.identifier.issn0951-4198zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34172-
dc.description.abstractLiquid chromatography/mass spectrometry (LC/MS) and liquid chromatography/tandem mass spectrometry (LC/MS/MS) were applied to characterize drug metabolites. Although these two methods have overcome the identification and structural characterization of metabolites analysis, they remain time-consuming processes. In this study, a novel multiple-stage tandem mass spectrometric method (MS(n)) was evaluated for identification and characterization of new minor metabolism profiling of penicillin G, one of the beta-lactam antibiotics, in human serum. Seven minor metabolites including five phase I metabolites and two phase II metabolites of penicillin G were identified by using data-dependent LC/MS(n) screening in one chromatographic run. The accuracy masses of seven identified metabolites of penicillin G were also confirmed by mass spectral calibration software (MassWorks (TM)). The proposed data-dependent LC/MS(n) method is a powerful tool to provide large amounts of the necessary structural information to characterize minor metabolite in metabolism profiling. Copyright (C) 2010 John Wiley & Sons, Ltd.en_US
dc.language.isoen_USzh_TW
dc.relationRapid Communications in Mass Spectrometryen_US
dc.relation.ispartofseriesRapid Communications in Mass Spectrometry, Volume 25, Issue 1, Page(s) 25-32.en_US
dc.relation.urihttp://dx.doi.org/10.1002/rcm.4823en_US
dc.subjectbeta-lactam antibioticsen_US
dc.subjectliquid-chromatographyen_US
dc.subjectallergyen_US
dc.subjectacidsen_US
dc.subjectplasmaen_US
dc.titleIdentification of new minor metabolites of penicillin G in human serum by multiple-stage tandem mass spectrometryen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1002/rcm.4823zh_TW
item.languageiso639-1en_US-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeJournal Article-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextno fulltext-
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