Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34176
DC FieldValueLanguage
dc.contributor.authorChen, C.Y.en_US
dc.contributor.author李茂榮zh_TW
dc.contributor.authorLee, M.R.en_US
dc.contributor.authorCheng, F.C.en_US
dc.contributor.authorWu, G.J.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-06T07:47:18Z-
dc.date.available2014-06-06T07:47:18Z-
dc.identifier.issn0039-9140zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34176-
dc.description.abstractWe have developed an analytical method by using liquid chromatography-mass spectrometry (LC-MS) to determine ketamine and its metabolites in urine. The ionization efficiency between two ionization modes (ESI and APCI) of LC-MS was compared to each other. An easy and simple sample preparation of urine samples was made by passing samples through a 0.22 mu m PVDF syringe filter. The results indicated that the ionization efficiency of positive APCI mode is better than positive ESI mode for determination of trace ketamines. A wide linearity range of the research is from 5 to 250 ng mL(-1) and the detection limits for ketamine, norketarnine and dehydronorketamine were 0.95, 0.48 and 0.33 ng mL(-1), respectively. The proposed method was tested by analyzing ketamine and metabolites in the urines of volunteers. The concentrations of ketamine, norketamine and dehydronorketamine are ranged of 5.4-131.0, 12.5-74.1 and 22.8-278.9 ng mL(-1), respectively and the ketamines concentration profiles in human urine were also determined. The results demonstrate the suitability of liquid chromatography-mass spectrometry approach to analyze trace amount of ketamine and its metabolites in urine. (C) 2007 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USzh_TW
dc.relationTalantaen_US
dc.relation.ispartofseriesTalanta, Volume 72, Issue 3, Page(s) 1217-1222.en_US
dc.relation.urihttp://dx.doi.org/10.1016/j.talanta.2007.01.016en_US
dc.subjectketamineen_US
dc.subjectmetabolitesen_US
dc.subjectliquid chromatography-mass spectrometryen_US
dc.subjectelectrospray ionizationen_US
dc.subjectatmospheric pressure chemical ionizationen_US
dc.subjectsolid-phase microextractionen_US
dc.subjectmicellar electrokinetic chromatographyen_US
dc.subjectamphetamine-type substancesen_US
dc.subjecthuman plasmaen_US
dc.subjectelectrospray-ionizationen_US
dc.subjectchemical derivatizationen_US
dc.subjecthair analysisen_US
dc.subjectnorketamineen_US
dc.subjectdehydronorketamineen_US
dc.subjectcapillaryen_US
dc.titleDetermination of ketamine and metabolites in urine by liquid chromatography-mass spectrometryen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1016/j.talanta.2007.01.016zh_TW
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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