Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34318
DC FieldValueLanguage
dc.contributor.authorJeng, C.C.en_US
dc.contributor.author鄭建宗zh_TW
dc.contributor.authorCheng, S.H.en_US
dc.contributor.authorHo, J.A.A.en_US
dc.contributor.authorHuang, S.H.Y.en_US
dc.contributor.authorChang, J.C.en_US
dc.contributor.authorTsai, P.J.en_US
dc.contributor.authorYang, C.S.en_US
dc.contributor.authorLo, L.W.en_US
dc.date2011zh_TW
dc.date.accessioned2014-06-06T07:47:33Z-
dc.date.available2014-06-06T07:47:33Z-
dc.identifier.issn1687-4110zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34318-
dc.description.abstractNanoparticle-mediated drug delivery and controlled release has been a vigorous research area in contemporary nanomedicine. The in vivo stability of nanoparticle delivered on site is a prerequisite for the design of drug-controlled release by any means. In this study, the first methodology comprised of microdialysis and optical imaging to assess the liposome stability in vivo is reported. Macroscopically, we demonstrated the DPPG liposomes with negative surface charge fast accumulated in the rat liver upon their i.v. administration using optical imaging. Microscopically, the concurrent analysis of fluorescent molecules leaching from the liposomes, in situ sampled using microdialysis probe, provides the dynamic information of stability of DPPG liposomes locus in quo. The current combination of in situ microdialysis and optical imaging possesses a great potential for use as a platform technology to evaluate the nanoparticle stability and the bioavailability of drug payload released on targeted site in vivo.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Nanomaterialsen_US
dc.relation.ispartofseriesJournal of Nanomaterials.en_US
dc.relation.urihttp://dx.doi.org/10.1155/2011/932719en_US
dc.subjectsurface-chargeen_US
dc.subjectclearanceen_US
dc.subjectpermeabilityen_US
dc.subjectmiceen_US
dc.titleDynamic Probing of Nanoparticle Stability In Vivo: A Liposomal Model Assessed Using In Situ Microdialysis and Optical Imagingen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1155/2011/932719zh_TW
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeJournal Article-
item.cerifentitytypePublications-
item.fulltextno fulltext-
item.languageiso639-1en_US-
item.grantfulltextnone-
Appears in Collections:奈米科學研究所
Show simple item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.