Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34402
DC FieldValueLanguage
dc.contributor.authorChiou, S.Y.en_US
dc.contributor.author林彥甫zh_TW
dc.contributor.authorWu, Y.G.en_US
dc.contributor.authorLin, Y.F.en_US
dc.contributor.authorLin, L.Y.en_US
dc.contributor.authorLin, G.L.en_US
dc.date2007zh_TW
dc.date.accessioned2014-06-06T07:47:39Z-
dc.date.available2014-06-06T07:47:39Z-
dc.identifier.issn1095-6670zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34402-
dc.description.abstractCarbamates are used to treat Alzheimer's disease. These compounds inhibit acetylcholinesterase and butyrylcholinesterase. The goal of this work is to use the substrate analogs of butyrylcholinesterase, 3,3-dimethylbutyl-N-n-butylcarbamate (1) and 2-trimethylsilyl-ethyl-N-n-butylcarbamate (2) to probe the substrate activation mechanism of butyrylcholinesterase. Compounds 1 and 2 are characterized as the pseudo substrate inhibitors of acetylcholinesterase; however, compounds 1 and 2 are characterized as the essential activators of butyrylcholinesterase. Therefore, compounds 1 and 2 mimic the substrate in the acetylcholinesterase-catalyzed reactions, but the behavior of compounds 1 and 2 mimics the substrate activation in the butyrylcholinesterase-catalyzed reactions. (c) 2007 Wiley Periodicals, Inc.en_US
dc.language.isoen_USzh_TW
dc.relationJournal of Biochemical and Molecular Toxicologyen_US
dc.relation.ispartofseriesJournal of Biochemical and Molecular Toxicology, Volume 21, Issue 1, Page(s) 24-31.en_US
dc.relation.urihttp://dx.doi.org/10.1002/jbt.20158en_US
dc.subjectbutyrylcholinesteraseen_US
dc.subjectacetylcholinesteraseen_US
dc.subjectcarbamatesen_US
dc.subjectactivatoren_US
dc.subjectinhibitoren_US
dc.subjectstructure-reactivity relationshipsen_US
dc.subjectsteady-state kineticsen_US
dc.subjectcholesterolen_US
dc.subjectesteraseen_US
dc.subjectmolecular recognitionen_US
dc.subjectcholinesterasesen_US
dc.subjectsiteen_US
dc.subjectmechanismen_US
dc.subjectbindingen_US
dc.subjecthydrolysisen_US
dc.subjectrivastigmineen_US
dc.titleSubstrate activation of butyrylcholinesterase and substrate inhibition of acetylcholinesterase by 3,3-dimethylbutyl-N-n-butylcarbamate and 2-trimethylsilyl-ethyl-N-n-butylcarbamateen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1002/jbt.20158zh_TW
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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