Please use this identifier to cite or link to this item: http://hdl.handle.net/11455/34417
DC FieldValueLanguage
dc.contributor.authorChiou, S.Y.en_US
dc.contributor.author林家立zh_TW
dc.contributor.authorHuang, C.F.en_US
dc.contributor.authorYeh, S.J.en_US
dc.contributor.authorChen, I.R.en_US
dc.contributor.authorLin, G.L.en_US
dc.date2010zh_TW
dc.date.accessioned2014-06-06T07:47:40Z-
dc.date.available2014-06-06T07:47:40Z-
dc.identifier.issn0899-0042zh_TW
dc.identifier.urihttp://hdl.handle.net/11455/34417-
dc.description.abstractThe acetylcholinesterase inhibition by enantiomers of exo- and endo-2norbornyl-N-n-butylcarbamates shows high stereoselelectivity. For the acetylcholinesterase inhibitions by (R)-(+)- and (S)-(-)-exo-2-norbornyl-N-n-butylcarbamates, the R-enantiomer is more potent than the S-enantiomer. But, for the acetylcholinesterase inhibitions by (R)-(+)- and (S)-(-)-endo-2-norbornyl-N-n-butylcarbamates, the S-enantiomer is more potent than the R-enantiomer. Optically Pure (R)-(+)-exo-, (S)-(-)-exo-, (R)-H-endo-, and (S)-(-)-endo-2-norbornyl-N-n-butylcarbamates are synthesized from condensations of optically pure (R)-(+)-exo-, (S)-(-)-exo-, (R)-(+)-endo-, and (S)-(-)-endo-2-norborneols with n-butyl isocyanate, respectively. Optically pure norborneols are obtained from kinetic resolutions of their racemic esters by lipase catalysis in organic solvent. Chirality 22:267-274, 2010. (C) 2009 Wiley-liss, Inc.en_US
dc.language.isoen_USzh_TW
dc.relationChiralityen_US
dc.relation.ispartofseriesChirality, Volume 22, Issue 2, Page(s) 267-274.en_US
dc.relation.urihttp://dx.doi.org/10.1002/chir.20739en_US
dc.subjectacetylcholinesteraseen_US
dc.subjectcarbamate inhibitoren_US
dc.subjectenantiomeren_US
dc.subjectstereoselectivityen_US
dc.subjectresolution by lipaseen_US
dc.subjectstructure-reactivity relationshipsen_US
dc.subjectpre-steady-stateen_US
dc.subjectcholesterolen_US
dc.subjectesteraseen_US
dc.subjectalzheimers-diseaseen_US
dc.subjectmolecular recognitionen_US
dc.subjectbutyrylcholinesteraseen_US
dc.subjectmechanismen_US
dc.subjectlipaseen_US
dc.subjectsiteen_US
dc.subjectcholinesterasesen_US
dc.titleSynthesis of Enantiomers of exo-2-Norbornyl-N-n-butylcarbamate and endo-2-Norbornyl-N-n-butylcarbamate for Stereoselective Inhibition of Acetylcholinesteraseen_US
dc.typeJournal Articlezh_TW
dc.identifier.doi10.1002/chir.20739zh_TW
item.grantfulltextnone-
item.openairetypeJournal Article-
item.languageiso639-1en_US-
item.fulltextno fulltext-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
Appears in Collections:化學系所
Show simple item record
 

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.